Abstract
The results of the first study on the effects of multi-walled carbon nanotubes (MWNTs) on the exploratory activity and the emotional state in laboratory rats assessed by the open field test are reported. During three or ten days, rats received 8–10 nm MWNTs added to their food at a dose of 500 mg/kg. It was demonstrated that, in the group of rats which were fed with MWNTs, the integrated anxiety level index began to increase as early as the third day of the experiment; on the tenth day, it appeared to be twice increased. It was also demonstrated that MWNTs decreased the integrated exploratory activity index nearly twofold on the third day and nearly fourfold on the tenth day.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Grigor’ev, N.R., Zh. Vyssh. Nervn. Deyat., 1996, vol. 46, no. 2, pp. 400–405.
Grigor’ev, N.R., Kirichenko, E.F., Temper, Yu.B., and Cherbikova, G.E., Zh. Vyssh. Nervn. Deyat., 1998, vol. 48, no. 5, pp. 868–876.
Liu, X., Zhang, Y., Li, J., et al., Int. J. Nanomed., 2014, vol. 9, pp. 823–839.
Xie, Y., Wang, Y., Zhang, T., et al., J. Biomed. Sci., 2012, no. 19, p. 14.
Dal Bosco, L., Weber, G.E.B., Parfitt, G.M., et al., Biomed. Res. Int., 2015, vol. 2015, p. 104135.
Hall, C.S., J. Comp. Psychol., 1934, no. 18, pp. 385–403.
Hall, C.S., J. Comp. Psychol., 1936, no. 22, pp. 345–452.
Latyushin, Ya.V., Kaleskova, Yu.G., Mamylina, N.V., and Pavlova, V.I., Vestn. Yuzhno-Ural. Gos. Univ., 2006, no. 3/1, pp. 178–179.
Vdovina, N.V., Klintsova, E.S., and Shcherbatyuk, T.G., Sovrem. Tekhnol. Med., 2010, no. 2, pp. 12–16.
Ivanov, D.G. and Podkovkin, V.G., Usp. Sovrem. Estestvozn., 2010, no. 5, pp. 16–20.
Batalova, T.A., Psychobiological characteristics in integrated correction in rats, Extended Abstract of Doctoral (Biol.) Dissertation, Blagoveshchensk, 2011.
Buslovich, S.Yu., Kotelenets, A.I., and Fridlyand, P.M., Zh. Vyssh. Nervn. Deyat., 1989, vol. 39, no. 1, pp. 168–171.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © N.V. Sayapina, T.A. Batalova, V.V. Chaika, V.L. Kuznetsov, A.A. Sergievich, V.P. Kolosov, Yu.M. Perel’man, K.S. Golokhvast, 2015, published in Doklady Akademii Nauk, 2015, Vol. 464, No. 1, pp. 115–117.
Rights and permissions
About this article
Cite this article
Sayapina, N.V., Batalova, T.A., Chaika, V.V. et al. Multi-walled carbon nanotubes increase anxiety levels in rats and reduce exploratory activity in the open field test. Dokl Biol Sci 464, 223–225 (2015). https://doi.org/10.1134/S0012496615050026
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0012496615050026