Abstract
Wistar rats were subjected to renovascular hypertension. Then, we studied two pools of neurons: intranuclear neurons located in projection area of the solitary tract nucleus and reticular, magnocellular, and parvicellular nuclei; and two groups of internuclear neurons, which included both small neurons 50–300 µm2 in size and large neurons more than 350 µm2 in size. Immunohistochemical methods with antisera against neuronal nitric oxide synthase, cystathionine-β-synthase, and heme oxygenase-2 were used. The studies were performed 8, 16, and 24 weeks after the development of renovascular hypertension. We have found that at least two pools of interneurons, intra- and internuclear cells, may be involved in the mechanisms of regulation of hemodynamics. These pools of interneurons differ in some topochemical and functional features, including different resistances to an increased blood pressure.
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References
Bokeriya, L.A. and Lishchuk, V.A., Klin. Fiziol. Kro-voobr., 2008, no. 2, pp. 53–67.
Val’dman, A.V., Neirofarmakologiya tsentral’noi regu-lyatsii sosudistogo tonusa (Neuropharmacology of the Central Regulation of the Vascular Tone), Leningrad Meditsina, 1976.
Kotsyuba, A.E. and Chertok, V.M., Zh. Nevrol. Psikhi-atrii, 2012, no. 1, pp. 54–59.
Sosunov, A.A., Soros. Obrazovat. Zh., 2000, no. 12, pp. 27–34.
Chertok, V.M. and Kotsyuba, A.E., Tikhookean. Med. Zh., 2012, no. 2, pp. 17–26.
Chertok, V.M. and Kotsyuba, A.E., Strukturnaya orga-nizatsiya bul’barnogo otdela serdechno-sosudistogo tsen-tra (Structural Organization of the Bulbar Division of the Cardiovascular Center), Vladivostok Meditsina, 2013.
Aicher, S.A., Reis, D.J., Ruggiero, D.A., and Milner, T.A., Neuroscience, 1994, vol. 60, no. 3, pp. 761–779.
Catalano, C. and Rastelli, S., Nephrology Dialysis Transplantation, 2009, vol. 24, no. 5, pp. 1394–1396.
Dampney, R.A., Physiol. Rev., 1994, vol. 74, pp. 323–364.
Esplugues, J.V., Brit. J. Pharm., 2002, vol. 135, no. 5, pp. 1079–1095.
Gadalla, M.M. and Snayder, S.H., J. Neurochem., 2010, vol. 113, pp. 14–26.
Jeske, I., Morrison, S.L., Cravo, S.L., and Reis, D.J., Am. J. Physiol., 1993, vol. 264.
Kishi, T., Hirooka, Y., Sakai, K., et al., Hypertension, 2001, vol. 38, pp. 896–901.
Kishi, T., Hirooka, Y., Kimura, Y., et al., Hypertension, 2003, vol. 41, pp. 255–260.
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Original Russian Text © V.M. Chertok, A.E. Kotsyuba, E.P. Kotsyuba, M.S. Startseva, 2015, published in Doklady Akademii Nauk, 2015, Vol. 463, No. 5, pp. 619–623.
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Chertok, V.M., Kotsyuba, A.E., Kotsyuba, E.P. et al. Two pools of interneurons in the bulbar region of the cardiovascular center of rats. Dokl Biol Sci 463, 178–182 (2015). https://doi.org/10.1134/S0012496615040079
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DOI: https://doi.org/10.1134/S0012496615040079