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Inclusion of Magnetite Nanoparticles Stabilized with Cetyltrimethylammonium Bromide in Soy Lecithin-Based Liposomes

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Abstract

Liposomes provide high biocompatibility with the cells of the human body due to the prevalence of membrane lipids in their composition. They can be used as an effective tool for targeted delivery of drugs against diseases of different etiology. Interactions between liposomes and target cells can be different, i.e., adsorption on the cell surface, endocytosis, and fusion of liposomes with cell membranes. The incorporation of magnetic nanoparticles into liposomes for active control using an external magnetic field makes it possible to enhance the efficiency and rate of drug release. To create magnetically controlled liposomes, we have chosen nanostructured magnetite created in our laboratory. We used nanoparticles with a diameter of 4.23 ± 1.19 nm. The surface of synthesized magnetite nanoparticles was covered with molecules of cetyltrimethylammonium bromide (CTAB), followed by inclusion into phosphatidylcholine-based liposomes. The quantitative analysis of magneto-sensitive nanoparticles embedded in the lipid bilayer was carried out by spectral methods and transmission electron microscopy. This study has shown that modification of nanostructured magnetite with CTAB increases the efficiency of the incorporation of magnetite nanoparticles into the lipid bilayer by 31.6%.

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ACKNOWLEDGMENTS

The studies were carried out using the equipment of the laboratory of electron microscopy at the Center for the Collective Use of Scientific Equipment of Voronezh State University (the size control of the nanoparticles) and the sector of electron microscopy at the Center for the Collective Use of the Federal Research Center “Pushchinsky Scientific Center for Biological Research of the Russian Academy of Sciences” (studies of liposome samples by transmission electron microscopy).

Funding

The work was supported by the RF Ministry of Science and Higher Education as part of the state assignment for universities in the field of scientific activity for 2020-2022, project no. FZGU-2020-0044.

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Authors and Affiliations

  1. Voronezh State University, 394018, Voronezh, Russia

    E. V. Shilova, I. A. Koltakov, S. V. Kannykin & V. G. Artyukhov

Authors
  1. E. V. Shilova
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  2. I. A. Koltakov
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  3. S. V. Kannykin
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  4. V. G. Artyukhov
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Corresponding author

Correspondence to E. V. Shilova.

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Conflict of interest. The authors declare that they have no conflicts of interest.Statement of the welfare of animals. The article does not contain any studies involving animals in experiments performed by any of the authors.

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Translated by A. Levina

Abbreviations: CTAB, cetyltrimethylammonium bromide.

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Shilova, E.V., Koltakov, I.A., Kannykin, S.V. et al. Inclusion of Magnetite Nanoparticles Stabilized with Cetyltrimethylammonium Bromide in Soy Lecithin-Based Liposomes. BIOPHYSICS 67, 435–439 (2022). https://doi.org/10.1134/S0006350922030216

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  • DOI: https://doi.org/10.1134/S0006350922030216

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