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The Nitrosonium Cation as a Component of Dinitrosyl Iron Complexes Mediates their Antitumor Effect

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Abstract—The antitumor efficacy of the combined use of the binuclear dinitrosyl iron complex with glutathione as an exogenous donor of cytotoxic nitrosonium cations and sodium diethyldithiocarbamate has been explored in a model study of mice with Lewis lung carcinoma. The tumor-inhibiting effects of the dinitrosyl iron complex (2 μM/kg, IV), sodium diethyldithiocarbamate (250 μM/kg, IP), and their combination were 48, 76, and 57%, respectively. These results suggest that the effect is determined by the ability of sodium diethyldithiocarbamate to decompose endogenous dinitrosyl iron complexes in tumors, so that nitrosonium cations are released from these complexes, thereby enhancing the antitumor effect of the concomitant medication to some extent.

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Authors and Affiliations

  1. Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, 119991, Moscow, Russia

    A. F. Vanin

  2. Institute of Regenerative Medicine, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 119991, Moscow, Russia

    A. F. Vanin

  3. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    L. A. Ostrovskaya, D. B. Korman, N. V. Bluhterova, V. A. Rykova & M. M. Fomina

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  1. A. F. Vanin
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  2. L. A. Ostrovskaya
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  3. D. B. Korman
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  4. N. V. Bluhterova
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  5. V. A. Rykova
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  6. M. M. Fomina
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Correspondence to A. F. Vanin.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by V. Gulevich

Abbreviations: M- and B-DNICs, mono- and binuclear dinitrosyl iron complexes; IP, intraperitoneal; IV, intravenous; DETC, sodium diethyldithiocarbamate; B-DNIC-GSH, binuclear dinitrosyl iron complex with glutathione; GS-NO, S‑nitrosoglutathione.

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Vanin, A.F., Ostrovskaya, L.A., Korman, D.B. et al. The Nitrosonium Cation as a Component of Dinitrosyl Iron Complexes Mediates their Antitumor Effect. BIOPHYSICS 66, 1037–1040 (2021). https://doi.org/10.1134/S0006350921060191

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  • DOI: https://doi.org/10.1134/S0006350921060191

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