Abstract
The effects of ozone on oxygen transport in the blood of experimental animals have been studied in vitro. Incubation of the blood with ozonated water at О3 concentrations of 2, 6, and 10 mg/L for 30 and 60 min caused changes in the oxygen-transport function of the blood, thus leading to increased oxygen tension and oxygenation, as well as reduced affinity of hemoglobin for oxygen. As a result, the content of the gaseous transmitters, such as nitric oxide and hydrogen sulfide, significantly increased, thus contributing to modification of the oxygen-binding properties of blood.
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Conflict of interests. The authors declare that they have no conflicts of interest.Statement on the welfare of animals. Manipulations with animals were performed following the recommendations and permission from the Regional Commission on Biomedical Ethics.
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Translated by A. Levina
Abbreviations: 2,3-DPG—2,3-diphosphoglycerate; HOA— hemoglobin-oxygen affinity.
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Zinchuk, V.V., Biletskaya, E.S. Different Dosage Effects of Ozone on Oxygen Transport in Blood during in vitro Experiments. BIOPHYSICS 65, 779–783 (2020). https://doi.org/10.1134/S0006350920050231
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DOI: https://doi.org/10.1134/S0006350920050231