Abstract—Using the animal model of rhabdomyolysis-induced acute kidney injury have revealed a significant nephroprotective effect of ademetionine by ability to eliminate the toxic action of myoglobin, manifested by an increase in diuresis, and glomerular filtration rate, a reduction of retention azotemia and proteinuria, the normalization of ion-regulating kidney function, an activation of the glomerular–tubular and tubular–tubular balances, and an improvement energy supply to the kidneys. A significant antioxidant effect of ademetionine has been confirmed with evidence that catalase and glutathione peroxidase activities were increased in kidney tissue with a significant decrease in lipid peroxidation and protein degradation. A cytoprotective efficacy was proven due to a decrease in gamma glutamyl transpeptidase activity in the urine of experimental animals.
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Statement on the welfare of animals. Experiments with animals were conducted in accordance with the provisions of Directive 2010/63/EU of the European Parliament and of the Council on the Protection of Animals Used for Scientific Purposes [21].
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Abbreviations: AKI, acute kidney injury; GFR, glomerular filtration rate; SAM, ademetionine.
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Zamorskii, I.I., Drachuk, V.M., Shchudrova, T.S. et al. Amelioration of Rhabdomyolysis-Induced Acute Kidney Injury by Ademetionine. BIOPHYSICS 64, 799–803 (2019). https://doi.org/10.1134/S0006350919050257
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DOI: https://doi.org/10.1134/S0006350919050257