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The Impact of Stochastic Perturbations upon the Hydrodynamic Relationship between the Activity of Human Cardiac Ventricles and Low-Frequency Blood Flow Oscillations in the Microcirculatory Bed

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Abstract—The experimentally revealed high phase coherence between low-frequency oscillations in the cutaneous blood perfusion signal at the contralateral skin sites indicates the existence of a central mechanism of its regulation. The vascular bed can be such a regulatory mechanism because it is a closed hydrodynamic system. It has been shown in this study using a mathematical model of the human cardiovascular system that the impact of low-intensity stochastic perturbations on the stiffness of the cardiac ventricles leads to the formation of low-frequency oscillations in microvascular blood flow. The results show that there is a relationship between the activity of the heart and low-frequency oscillations of microcirculatory skin blood flow, which is due to the hydrodynamic properties of the vascular bed without the involvement of autonomous control from autonomic nervous system.

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Funding

This work was supported by the Russian Science Foundation, project no. 16-15-00248.

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    A. A. Grinevich, A. V. Tankanag & N. K. Chemeris

  2. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    A. A. Grinevich

Authors
  1. A. A. Grinevich
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  2. A. V. Tankanag
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  3. N. K. Chemeris
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Correspondence to A. A. Grinevich.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by E. Puchkov

Abbreviations: CVS, cardiovascular system; MCB, microcirculatory bed; UVR, united vascular reservoir; EHR, efficient hydrodynamic resistance; WNLFB, white noise with limited frequency band.

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Grinevich, A.A., Tankanag, A.V. & Chemeris, N.K. The Impact of Stochastic Perturbations upon the Hydrodynamic Relationship between the Activity of Human Cardiac Ventricles and Low-Frequency Blood Flow Oscillations in the Microcirculatory Bed. BIOPHYSICS 64, 117–128 (2019). https://doi.org/10.1134/S000635091901007X

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  • DOI: https://doi.org/10.1134/S000635091901007X

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