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A Number of Properties of Proto-Mitochondria from Rat Liver

  • Cell Biophysics
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Abstract

A number of properties of isolated proto-mitochondria (small young animal cell organelles) were studied. Proto-mitochondria were obtained by filtration of the light fraction of rat-liver mitochondria through calibrated millipore filters with a pore diameter of 0.45 μm. It was found that proto-mitochondria have a decreased ability to synthesize ATP due to their much lower content of ATP synthetase. The level of cytochromes in proto-mitochondria and mitochondria differ little. It was found that proto-mitochondria have more flavoproteins than mitochondria. It was demonstrated that proto-mitochondria (unlike mitochondria) contain almost none of the lipofuscin “aging pigment.” These differences reflect the processes of intracellular maturation of proto-mitochondria to mitochondria and subsequent aging to post-mitochondria. The results are important for understanding the role of proto-mitochondria in the cellular metabolism of specialized animal cells.

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia

    K. E. Krekhova & N. L. Vekshin

Authors
  1. K. E. Krekhova
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  2. N. L. Vekshin
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Correspondence to N. L. Vekshin.

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Original Russian Text © K.E. Krekhova, N.L. Vekshin, 2018, published in Biofizika, 2018, Vol. 63, No. 2, pp. 265–269.

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Krekhova, K.E., Vekshin, N.L. A Number of Properties of Proto-Mitochondria from Rat Liver. BIOPHYSICS 63, 183–186 (2018). https://doi.org/10.1134/S000635091802015X

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  • DOI: https://doi.org/10.1134/S000635091802015X

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