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Integrated mathematical models for describing complex biological processes

  • Biophysics of Complex Systems
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Abstract

This review describes integrated mathematical models of processes, such as calcium homeostasis, pathogen–host interaction (with hepatitis C virus as a pathogen), and the response of the human brain to a stimulating event. It is shown that integrated mathematical models provide a deeper insight into the mechanisms and conditions that lead to the development of diseases of different natures (musculoskeletal disorders, viral infections, and various impairments in brain function) and aid identification of the key targets and conditions for a directed effect of new generation drugs, as well as the interpretation of the results of state-of-theart CT imaging.

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Abbreviations

MAPK:

mitogen-activated protein kinase

TGF-ß:

transforming growth factor

HCV:

hepatitis C virus

PTH:

parathyroid hormone

RANK:

receptor activator of nuclear factor NF-κB

RANKL:

RANK ligand

OPG:

osteoprotegerin

IFN-a:

interferon a

fMRI:

functional magnetic resonance imaging

MRS:

magnetic resonance spectroscopy

BOLD signal:

blood oxygen level–dependent signal

ANLS:

astrocyte–neuron lactate shuttle

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    E. L. Mishchenko, O. V. Petrovskaya, E. D. Petrovskiy, N. V. Ivanisenko & V. A. Ivanisenko

  2. Novosibirsk State University, Novosibirsk, 630090, Russia

    A. M. Mishchenko

Authors
  1. E. L. Mishchenko
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  2. O. V. Petrovskaya
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  3. A. M. Mishchenko
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  4. E. D. Petrovskiy
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  5. N. V. Ivanisenko
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  6. V. A. Ivanisenko
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Correspondence to E. L. Mishchenko.

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Original Russian Text © E.L. Mishchenko, O.V. Petrovskaya, A.M. Mishchenko, E.D. Petrovskiy, N.V. Ivanisenko, V.A. Ivanisenko, 2017, published in Biofizika, 2017, Vol. 62, No. 5, pp. 949–968.

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Mishchenko, E.L., Petrovskaya, O.V., Mishchenko, A.M. et al. Integrated mathematical models for describing complex biological processes. BIOPHYSICS 62, 778–795 (2017). https://doi.org/10.1134/S0006350917050141

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