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The response of the mononuclear phagocyte system to chronic hyperglycemia

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Abstract

In this study we revealed a common reaction of cells of the mononuclear phagocyte system in the central and peripheral immunopoietic organs and pancreas in rats with chronic hyperglycemia. The activation of monocytopoiesis and recruitment of mononuclear phagocytes in peripheral tissues were observed. The modulation of the functional activity of mononuclear phagocytes by 3-aminophthal-hydrazide contributed to the normalization of monocytopoietic intensity and a decrease in the level of macrophagal infiltration in the thymus, pancreas, and peripancreatic lymph nodes. These changes indicate that mononuclear phagocytes are involved in the adaptive response to chronic hyperglycemia.

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Abbreviations

CH:

chronic hyperglycemia

MPS:

mononuclear phagocyte system

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Authors and Affiliations

  1. Ural Federal University named after the first President of Russia B.N. Yeltsin, ul. Mira 19, Yekaterinburg, 620002, Russia

    T. S. Bulavintseva, I. G. Danilova, S. A. Briliant & S. E. Smirnyh

  2. Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 106, Yekaterinburg, 620049, Russia

    T. S. Bulavintseva, I. G. Danilova, S. A. Briliant & S. E. Smirnyh

  3. Institute of Medical Cell Technologies, ul. K. Marksa 22a, Yekaterinburg, 620026, Russia

    I. G. Danilova & S. A. Briliant

  4. Institute of Immunopathology, ul. Molodogvardeiskaya 57/1, Moscow, 121351, Russia

    M. T. Abidov

Authors
  1. T. S. Bulavintseva
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  2. I. G. Danilova
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  3. S. A. Briliant
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  4. S. E. Smirnyh
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  5. M. T. Abidov
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Corresponding author

Correspondence to T. S. Bulavintseva.

Additional information

Original Russian Text © T.S. Bulavintseva, I.G. Danilova, S.A. Briliant, S.E. Smirnyh, M.T. Abidov, 2016, published in Biofizika, 2016, Vol. 61, No. 5, pp. 936–940.

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Bulavintseva, T.S., Danilova, I.G., Briliant, S.A. et al. The response of the mononuclear phagocyte system to chronic hyperglycemia. BIOPHYSICS 61, 919–922 (2016). https://doi.org/10.1134/S0006350916050031

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  • DOI: https://doi.org/10.1134/S0006350916050031

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