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The combined effects of dietary supplements and low-dose-rate high-LET radiation on mice in vivo

  • Biophysics of Complex Systems
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Abstract

The purpose of this study was to investigate the combined actions of food supplements and lowdose-rate high-LET radiation on radiosensitivity, induction of the adaptive response, and tumor growth in SHK mice in vivo. The animals were irradiated with 0.11 Gy (0.005 Gy/day) of low-dose-rate high-LET radiation behind the concrete shield of a 70 GeV proton accelerator (Protvino, Moscow oblast). Four groups of the mice were fed with selected products (soy meat, buckwheat, lettuce leaves, and a drug based on cod-liver oil) during the entire irradiation period (22 days). The results of the study indicate that the mice with diets containing soy meat, buckwheat, and lettuce leaves in contrast to those fed with a diet containing cod-liver oil had reduced sensitivity to X-radiation at a dose rate of 1.5 Gy and a significant slowdown in the growth of the Ehrlich carcinoma. The combined effect of high-LET radiation and the food supplements mentioned above (except for the cod-liver oil) reduced the sensitivity of the mice to the irradiation at a dose rate of 1.5 Gy, induced the adaptive response, and caused a decrease in the growth rate of the Ehrlich carcinoma in contrast to the mice that were only irradiated with high-LET radiation.

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Abbreviations

LHR:

low-dose-rate high-LET radiation

EAC:

Ehrlich ascites carcinoma; polychromatocytes, polychro-matocyte

References

  1. Z. Guangming, K. Tetsuya, F. Yoshiya, et al., Radiat. Res. 47, 175 (2006).

    Article  Google Scholar 

  2. S. I. Zaichkina, O. M. Rozanova, A. Kh. Akhmadieva, et al., Aviakosm. Ekol. Med. 41 (6), 360 (2007).

    Google Scholar 

  3. L. M. Rozhdestvenskii, V. F. Mikhailov, T. G. Shlyakova, et al., Radiat. Biol. Radioekol. 55 (4), 420 (2015).

    Google Scholar 

  4. N. V. Kondakova, S. I. Zaichkina, O. M. Rozanova, et al., Vopr. Biol. Med. Farm. Khim. 4, 46 (2002).

    Google Scholar 

  5. S. Sorokina, S. Zaichkina, O. Rozanova, et al., in Proc. 37th Ann. Meeting of the European Radiation Research Society, Ed. by Jiri Skopek (Medimond Int. Proceed., Italy, 2009), pp. 79–82.

  6. A. A. Sun, H. C. Yeh, L. H. Wang, et al., Nutr. Cancer 39 (1), 85 (2001).

    Article  Google Scholar 

  7. O. V. Surkova, V. A. Budarkov, Yu. B. Kudryashov, et al., Radiat. Biol. Radioekol. 50 (5), 536 (2010).

    Google Scholar 

  8. J. Guan, J. Stewart, J. H. Ware, et al., Radiat. Res. 165 (4), 373 (2006).

    Article  Google Scholar 

  9. B. M. Rabin, B. Shukitt-Hale, A. Szprengiel, et al., Brain Res. 953, 31 (2002).

    Article  Google Scholar 

  10. B. M. Rabin, J. A. Joseph, B. Shukitt-Hale, et al., Adv. Space Res. 40, 576 (2007).

    Article  ADS  Google Scholar 

  11. M. Hada and A. Georgakilas, Radiat. Res. 49, 203 (2008).

    Article  Google Scholar 

  12. D. Li, G. Graef, J. A. Yee, et al., J. Nutr. 134, 1536 (2004).

    Google Scholar 

  13. H. L. Newmark, K. Yang, M. Lipkin, et al., Carcinogenesis 22 (11), 1871 (2001).

    Article  Google Scholar 

  14. T. Ushakova, H. Melkonyan, L. Nikonova, et al., Free Radic. Biol. Med. 26, 887 (1999).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Puschino, Moscow oblast, 142290, Russia

    S. S. Sorokina, S. I. Zaichkina, O. M. Rozanova, E. N. Smirnova, S. P. Romanchenko, A. E. Shemyakov & O. A. Vakhrusheva

  2. Physical Technical Center, Lebedev Physical Institute, Russian Academy of Sciences, Akademicheskii proezd 2 /110, Moscow oblast, Protvino, 142280, Russia

    V. E. Balakin

Authors
  1. S. S. Sorokina
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  2. S. I. Zaichkina
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  3. O. M. Rozanova
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  4. E. N. Smirnova
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  5. S. P. Romanchenko
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  6. A. E. Shemyakov
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  7. O. A. Vakhrusheva
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  8. V. E. Balakin
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Corresponding author

Correspondence to V. E. Balakin.

Additional information

Original Russian Text © S.S. Sorokina, S.I. Zaichkina, O.M. Rozanova, E.N. Smirnova, S.P. Romanchenko, A.E. Shemyakov, O.A. Vakhrusheva, V.E. Balakin, 2016, published in Biofizika, 2016, Vol. 61, No. 1, pp. 172–177.

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Sorokina, S.S., Zaichkina, S.I., Rozanova, O.M. et al. The combined effects of dietary supplements and low-dose-rate high-LET radiation on mice in vivo. BIOPHYSICS 61, 144–148 (2016). https://doi.org/10.1134/S0006350916010231

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  • DOI: https://doi.org/10.1134/S0006350916010231

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