Abstract
Using a spectrophotometric method, changes occurring in solution containing brain Aβ(1–42)-peptide, fullerene C60, and polyvinylpyrrolidone were analyzed. Using the Bent-French method, relative binding constants of fullerene C60 with Aβ(1–42)-peptide and polyvinylpyrrolidone with Aβ(1–42)-peptide were determined. These data suggest that Aβ(1–42)-peptide interacting with the C60 fullerene-polyvinylpyrrolidone complex partially displaces polyvinylpyrrolidone and generates a new three molecular compound.
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Original Russian Text © A.G. Bobylev, Yu.V. Shatalin, I.M. Vikhlyantsev, L.G. Bobyleva, S.V. Gudkov, Z.A. Podlubnaya, 2014, published in Biofizika, 2014, Vol. 59, No. 5, pp. 843–847.
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Bobylev, A.G., Shatalin, Y.V., Vikhlyantsev, I.M. et al. Interaction of C60 fullerene-polyvinylpyrrolidone complex and brain Aβ(1–42)-peptide in vitro. BIOPHYSICS 59, 685–688 (2014). https://doi.org/10.1134/S0006350914050054
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DOI: https://doi.org/10.1134/S0006350914050054