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Role of Nuclear Lamina in Gene Repression and Maintenance of Chromosome Architecture in the Nucleus

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Abstract

Nuclear lamina is a protein meshwork composed of lamins and lamin-associated proteins that lines the nuclear envelope from the inside and forms repressive transcription compartment. The review presents current data on the contribution of nuclear lamina to the repression of genes located in this compartment and on the mechanisms of chromatin attachment to the nuclear envelope.

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Abbreviations

DamID:

DNA adenine methyltransferase identification

FISH:

fluorescent in situ hybridization

LAD:

lamina-associated domain

LBR:

lamin B receptor

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, 123182, Moscow, Russia

    Y. Y. Shevelyov

  2. Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia

    S. V. Ulianov

  3. Lomonosov Moscow State University, Faculty of Biology, 119192, Moscow, Russia

    S. V. Ulianov

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Shevelyov, Y.Y., Ulianov, S.V. Role of Nuclear Lamina in Gene Repression and Maintenance of Chromosome Architecture in the Nucleus. Biochemistry Moscow 83, 359–369 (2018). https://doi.org/10.1134/S0006297918040077

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