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Circulating microRNAs

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Abstract

The detection of miRNAs in plasma and other body fluids opened up a fascinating possibility that animal noncoding RNAs can act as extracellular signaling molecules. In this review, we discuss recent progress in the field including the ability of miRNAs to participate in intercellular communication in vitro and in vivo, and the application of circulating miRNAs as diagnostic markers of a wide range of diseases. Special attention is paid to the relevance of the development and unification of current techniques for isolation of circulating miRNAs.

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Abbreviations

c-miRNAs:

circulating microRNAs

HDL:

high-density lipoproteins

RNP:

ribonucleoprotein

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia

    J. A. Makarova

  2. Scientific Research Center Bioclinicum, 115088, Moscow, Russia

    J. A. Makarova & M. U. Shkurnikov

  3. Hertsen Moscow Oncology Research Institute, Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation, 125284, Moscow, Russia

    M. U. Shkurnikov & A. G. Tonevitsky

  4. Molecular Epidemiology Group, German Cancer Research Center, 69120, Heidelberg, Germany

    A. A. Turchinovich

  5. Institute for Biomedical Problems, Russian Academy of Sciences, 123007, Moscow, Russia

    A. I. Grigoriev

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  1. J. A. Makarova
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  2. M. U. Shkurnikov
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  3. A. A. Turchinovich
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  4. A. G. Tonevitsky
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  5. A. I. Grigoriev
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Correspondence to J. A. Makarova.

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Published in Russian in Biokhimiya, 2015, Vol. 80, No. 9, pp. 1344–1355.

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Makarova, J.A., Shkurnikov, M.U., Turchinovich, A.A. et al. Circulating microRNAs. Biochemistry Moscow 80, 1117–1126 (2015). https://doi.org/10.1134/S0006297915090035

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  • DOI: https://doi.org/10.1134/S0006297915090035

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