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Mitochondria-targeted plastoquinone antioxidant SkQR1 has positive effect on memory of rats

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Abstract

A single intraperitoneal injection to rats of the mitochondria-targeted plastoquinone antioxidant SkQR1 at dose 1 μmol/kg significantly improved reproduction by the rats of the passive avoidance conditional reflex. In vitro experiments on hippocampal slices showed that a single intraperitoneal injection of SkQR1 24 h before the preparation of the slice significantly increases the synaptic transmission efficiency of the pyramidal neurons of the CA1 field. The findings indicate that SkQR1 has a positive effect on memory processes.

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Abbreviations

Abeta:

β-amyloid peptide 1-42

AD:

Alzheimer’s disease

HFS:

high-frequency stimulation

PACR:

passive avoidance conditioned reflex

PS:

population spike

ROS:

reactive oxygen species

SkQR1:

10-(6′-plastoquinonyl)decylrhodamine 19

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Authors and Affiliations

  1. Research Center of Neurology, Russian Academy of Medical Sciences, Volokolamskoe Shosse 80, 125367, Moscow, Russia

    E. V. Stelmashook, A. V. Stavrovskaya, N. G. Yamshchikova, A. S. Ol’shanskii, N. A. Kapay, O. V. Popova, L. G. Khaspekov, V. G. Skrebitsky & N. K. Isaev

  2. Institute of Mitoengineering, Lomonosov Moscow State University, 119991, Moscow, Russia

    E. V. Stelmashook, N. A. Kapay, O. V. Popova & N. K. Isaev

  3. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia

    N. K. Isaev

Authors
  1. E. V. Stelmashook
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  2. A. V. Stavrovskaya
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  3. N. G. Yamshchikova
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  4. A. S. Ol’shanskii
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  5. N. A. Kapay
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  6. O. V. Popova
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  7. L. G. Khaspekov
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  8. V. G. Skrebitsky
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  9. N. K. Isaev
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Corresponding author

Correspondence to N. K. Isaev.

Additional information

Original Russian Text © E. V. Stelmashook, A. V. Stavrovskaya, N. G. Yamshchikova, A. S. Ol’shanskii, N. A. Kapay, O. V. Popova, L. G. Khaspekov, V. G. Skrebitsky, N. K. Isaev, 2015, published in Biokhimiya, 2015, Vol. 80, No. 5, pp. 702–706.

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Stelmashook, E.V., Stavrovskaya, A.V., Yamshchikova, N.G. et al. Mitochondria-targeted plastoquinone antioxidant SkQR1 has positive effect on memory of rats. Biochemistry Moscow 80, 592–595 (2015). https://doi.org/10.1134/S0006297915050119

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  • DOI: https://doi.org/10.1134/S0006297915050119

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