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Pineal gland as an endocrine gravitational lunasensor: Manifestation of moon-phase dependent morphological changes in mice

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Abstract

We found that some morphological properties of the pineal gland and submandibular salivary gland of mice are significantly distinct at the new and full moon. We suppose that the differences are initiated by the displacements of the electron-dense concretions in the secretory vesicles of pinealocytes. This presumably occurs under the influence of the gravitational field, which periodically changes during different phases of the moon. It seems that the pinealocyte is both an endocrine and gravisensory cell. A periodic secretion of the pineal gland probably stimulates, in a lunaphasic mode, the neuroendocrine system that, in turn, periodically exerts influence on different organs of the body. The observed effect probably serves, within the lifelong clock of a brain, to control development and aging in time.

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References

  1. Karasek, M. (1992) Ultrastructure of the mammalian pinealocyte under natural and experimental conditions: quantitative aspects, Microsc. Res. Tech., 21, 116–123.

    Article  PubMed  CAS  Google Scholar 

  2. Karasek, M., and Reiter, R. J. (1992) Morphofunctional aspects of the mammalian pineal gland, Microsc. Res. Tech., 21, 136–157.

    Article  PubMed  CAS  Google Scholar 

  3. Karasek, M., Zielinska, A., Marek, K., and Swietoslawski, J. (2002) Effect of superior cervical ganglioectomy on the ultrastructure of pinealocytes in the Djungarian hamster (Phodopus sungorus): quantitative study, Neuroendocrinol. Lett., 23, 443–446.

    PubMed  Google Scholar 

  4. Reiter, R. J. (1981) Chronobiological aspects of the mammalian pineal gland, Prog. Clin. Biol. Res., 59C, 223–233.

    PubMed  CAS  Google Scholar 

  5. Sabry, I., Al-Ghaith, L., and Al-Azemi, M. (1999) Pineal gland of the Kuwaiti desert gerbil (Gerbillus cheesmani): alterations of its structure by bromocriptine treatment, Endocr. Regul., 33, 69–78.

    PubMed  CAS  Google Scholar 

  6. Logvinov, S. V., Gerasimov, A. V., and Kostyuchenko, V. P. (2004) Ultrastructure of pinealocytes in rats exposed to light and radiation, Morphology, 125, 71–75.

    PubMed  CAS  Google Scholar 

  7. Gerasimov, A. V., Logvinov, S. V., Kostyuchenko, V. P., and Kravchenko, L. B. (2012) Morphology of the pineal gland of mice with delayed puberty, Byul. Sib. Med., 10, 22–25.

    Google Scholar 

  8. Lewczuk, B., Nowicki, M., Prusik, M., and Przybylska-Gornowicz, B. (2004) Diurnal rhythms of pinealocyte ultra-structure, pineal serotonin content and plasma melatonin level in the domestic pig, Folia Histochem. Cytobiol., 42, 155–163.

    PubMed  Google Scholar 

  9. Olovnikov, A. (2005) Lunasensor, infradian rhythms, telomeres, and the chronomere program of aging, Ann. N. Y. Acad. Sci., 1057, 112–132.

    Article  PubMed  CAS  Google Scholar 

  10. Olovnikov, A. M. (2007) Hypothesis: Lifespan is regulated by chronomere DNA of the hypothalamus, J. Alzheimer’s Dis., 11, 241–252.

    CAS  Google Scholar 

  11. Cajochen, C., Altanay-Ekici, S., Munch, M., Frey, S., Knoblauch, V., and Wirz-Justice, A. (2013) Evidence that the lunar cycle influences human sleep, Curr. Biol., 23, 1485–1488.

    Article  PubMed  CAS  Google Scholar 

  12. Jayasinghe, N. R., Cope, G. H., and Jacob, S. (1990) Morphometric studies on the development and sexual dimorphism of the submandibular gland of the mouse, J. Anat., 172, 115–127.

    PubMed  CAS  PubMed Central  Google Scholar 

  13. Logvinov, S. V., and Gerasimov, A. V. (2007) Circadian System and Adaptation. Morphofunctional and Radiobiological Aspects [in Russian], Pechatnaya Manufaktura, Tomsk, p. 200.

    Google Scholar 

  14. Pongsa-Asawapaiboon, A., Asavaritikrai, P., Withyachumnarnkul, B., and Sumridthong, A. (1998) Melatonin increases nerve growth factor in mouse sub-mandibular gland, J. Pineal Res., 24, 73–77.

    Article  PubMed  CAS  Google Scholar 

  15. Allen, D. J., DiDio, L. J. A., and Gentry, E. R. (1982) The aged rat pineal gland as revealed in SEM and TEM, Age, 5, 119–126.

    Article  Google Scholar 

  16. Vollrath, L. (1984) Functional anatomy of the human pineal gland, in The Pineal Gland (Reiter, R. J., ed.) Raven Press, N. Y., pp. 285–322.

    Google Scholar 

  17. Gerasimov, A. V., Logvinov, S. V., and Kostyuchenko, V. P. (2010) Morphological changes in the pineal gland of rats after a prolonged exposure to illumination with bright light, Bull. Exp. Biol. Med., 150, 97–99.

    Article  Google Scholar 

  18. Denny, P. C., Chai, Y., Pimprapaiporn, W., and Denny, P. A. (1990) Three-dimensional reconstruction of adult female mouse submandibular gland secretory structures, Anat. Rec., 226, 489–500.

    Article  PubMed  CAS  Google Scholar 

  19. Tandler, B., Gresik, E. W., Nagato, T., and Phillips, C. J. (2001) Secretion by striated ducts of mammalian major salivary glands: review from an ultrastructural, functional, and evolutionary perspective, Anat. Rec., 264, 121–145.

    Article  PubMed  CAS  Google Scholar 

  20. Logvinov, S. V., Gerasimov, A. V., and Kostyuchenko, V. P. (2003) Structural changes in epitheliocytes of granular excretory ducts and terminal sections of submandibular glands of rats after exposure to light and radiation, Morphology, 124, 80–83.

    PubMed  CAS  Google Scholar 

  21. Ivanov, S. V. (2008) Substrates and possible mechanisms of pineal gland’s moon-sensory function in the context of redusome hypothesis of aging and control of biological time in ontogeny, Adv. Gerontol., 21, 488–490.

    PubMed  CAS  Google Scholar 

  22. Ivanov S. V., and Kostoglodov, Iu. K. (2010) Morphological and chronoepidemiological motivation of the pineal gland’s lunasensory function in the context of redumere hypothesis of aging, Adv. Gerontol., 23, 536–538.

    PubMed  CAS  Google Scholar 

  23. Zimecki, M. (2006) The lunar cycle: effects on human and animal behavior and physiology, Postepy Hig. Med. Dosw., 60, 1–7.

    Google Scholar 

  24. Skulachev, V. P., Skulachev, M. V., and Feniouk, B. A. (2013) Life with no Aging [in Russian], Eksmo, Moscow.

    Google Scholar 

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Authors and Affiliations

  1. Siberian State Medical University, Moscovskii Trakt 2, 634050, Tomsk, Russia

    A. V. Gerasimov & V. P. Kostyuchenko

  2. Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, 119334, Moscow, Russia

    A. S. Solovieva & A. M. Olovnikov

Authors
  1. A. V. Gerasimov
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  2. V. P. Kostyuchenko
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  3. A. S. Solovieva
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  4. A. M. Olovnikov
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Corresponding author

Correspondence to A. M. Olovnikov.

Additional information

Published in Russian in Biokhimiya, 2014, Vol. 79, No. 10, pp. 1316–1323.

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Gerasimov, A.V., Kostyuchenko, V.P., Solovieva, A.S. et al. Pineal gland as an endocrine gravitational lunasensor: Manifestation of moon-phase dependent morphological changes in mice. Biochemistry Moscow 79, 1069–1074 (2014). https://doi.org/10.1134/S0006297914100083

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  • DOI: https://doi.org/10.1134/S0006297914100083

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