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Plasticity of tumor cell migration: acquisition of new properties or return to the past?

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Abstract

During tumor development cancer cells pass through several stages when cell morphology and migration abilities change remarkably. These stages are named epithelial-mesenchymal and mesenchymal-amoeboid transitions. The molecular mechanisms underlying cell motility are changing during these transitions. As result of transitions the cells acquire new characteristics and modes of motility. Cell migration becomes more independent from the environmental conditions, and thus cell dissemination becomes more aggressive, which leads to formation of distant metastases. In this review we discuss the characteristics of each of the transitions, cell morphology, and the specificity of cellular structures responsible for different modes of cell motility as well as molecular mechanisms regulating each transition.

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Abbreviations

AMT:

amoeboid-mesenchymal transition

ECM:

extracellular matrix

EMT:

epithelial-mesenchymal transition

MAT:

mesenchymal-amoeboid transition

MMPs:

matrix metalloproteinases

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  1. Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Kashirskoe Shosse 24, 115478, Moscow, Russia

    A. Y. Alexandrova

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Published in Russian in Biokhimiya, 2014, Vol. 79, No. 9, pp. 1169–1187.

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Alexandrova, A.Y. Plasticity of tumor cell migration: acquisition of new properties or return to the past?. Biochemistry Moscow 79, 947–963 (2014). https://doi.org/10.1134/S0006297914090107

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