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A Method of Obtaining Silver–Succinyl Chitosan Nanocomposites and their Antimicrobial Activity

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Abstract

To form silver nanoparticles by reduction from metal ions in the presence of a reducing agent, D-glucose, a water-soluble derivative of chitosan, succinyl-chitosan, was used as a polymer matrix at room temperature. The synthesis of silver nanoparticles can also be carried out without a reducing agent by thermal activation of the system using an alkali (NaOH) as an accelerator. The presence of silver nanoparticles in the obtained colloidal solutions was judged by the appearance of an absorption band in the electron plasmon resonance spectra (ƛmax = 417 nm). It has been shown that the use of an additional component, polyethylene oxide, in a macromolecular system makes it possible to obtain small silver nanoparticles (1–3 nm). The results of in vitro studies of the antimicrobial activity of the obtained colloidal solutions containing silver nanoparticles confirm that a decrease in the size of silver nanoparticles leads to an expansion of the spectrum of antibacterial activity of strains of gram-positive and gram-negative bacteria (B. subtilis ATCC 6633, S. aureus 209P, E. coli ATCC 25922) and to the manifestation of a pronounced antifungal action in relation to A. niger INA 00760.

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Funding

The work was carried out within the framework of the State Assignment of the Topchiev Institute of Petrochemical Synthesis of the Russian Academy of Sciences.

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Authors and Affiliations

  1. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 119991, Moscow, Russia

    V. A. Aleksandrova & A. M. Futoryanskaya

  2. Gause Institute of New Antibiotics, 119021, Moscow, Russia

    V. S. Sadykova

Authors
  1. V. A. Aleksandrova
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  2. A. M. Futoryanskaya
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  3. V. S. Sadykova
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Corresponding authors

Correspondence to V. A. Aleksandrova or A. M. Futoryanskaya.

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The authors declare that they have no conflicts of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Aleksandrova, V.A., Futoryanskaya, A.M. & Sadykova, V.S. A Method of Obtaining Silver–Succinyl Chitosan Nanocomposites and their Antimicrobial Activity. Appl Biochem Microbiol 58, 641–645 (2022). https://doi.org/10.1134/S0003683822050040

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  • DOI: https://doi.org/10.1134/S0003683822050040

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