Abstract
Porous materials, cryogels and aerogels, were synthesized based on a sodium alginate–chitosan interpolymer complex via freeze-drying and supercritical drying. It was shown that the specific surface area of aerogels was approximately ten times higher than that of cryogels due to the developed mesoporous structure and amounted to 260 m2/g. The polyelectrolyte nature of the obtained materials, their dimensional stability, and their high water absorption (15 and 45 g/g for cryogel and aerogel, respectively) allowed us to use the obtained materials for sorption-application therapy. To impart antimicrobial properties, the materials were impregnated with usnic acid isolated from the lichen Usnea subfloridana, which has antibacterial activity against Escherichia coli bacteria and the microorganism species Staphylococcus aureus and Bacillus subtilis. It was shown that the minimum inhibitory concentration of usnic acid for these test cultures was 0.03 mg/mL. The resulting materials are capable of a slow release of usnic acid over 5 h, while its maximum release was 60% for aerogel and 30% for cryogel. The kinetics of usnic acid release of from both materials is adequately described by the Korsmeyer–Peppas equation.
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Funding
The studies were carried out in the course of the implementation of the State Task of the Federal Center for Integrated Arctic Research, the Ural Branch of the Russian Academy of Sciences, 2018–2021, “Physicochemical, genetic and morphological bases of the adaptation of plant objects under changing climate of high latitudes” (project no. АААА-А18-118012390231-9) on the equipment of the Arktika Center for Collective Use of Scientific Equipment (Northern (Arctic) Federal University) and the CT RF-Arktika Center for Collective Use (Federal Center for Integrated Arctic Research, the Ural Branch of the Russian Academy of Sciences).
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The authors declare that they have no conflicts of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.
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Gorshkova, N.A., Brovko, O.S., Palamarchuk, I.A. et al. Influence of the Structure of Alginate-Chitosan Materials on the Kinetics of Usnic Acid Release. Appl Biochem Microbiol 58, 110–117 (2022). https://doi.org/10.1134/S0003683822020089
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DOI: https://doi.org/10.1134/S0003683822020089