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Preparation and Properties of Nanocolloidal Rhenium Sulfide Solution for Lymphoscintigraphic Methods of Micrometastase Examination

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Abstract

A method for the preparation of a nanocolloidal solution of rhenium sulfide is proposed. It includes the following stages: interaction of ammonium perrhenate and sodium thiosulfate in an aqueous solution of gelatin in an acidic medium with heating to 70–80°C; neutralization to pH 7.0; dialysis against saline; desalination and concentrating by ultrafiltration. The resulting colloidal solution contains 85% of particles with an optimal size of 80–100 nm and can be used as a diagnostic tool for lymphoscintigraphy of sentinel lymph nodes in patients with cancer and other diseases.

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Authors and Affiliations

  1. Pharmaceutical Research and Production Enterprise Saluta-M, Istra, Moscow oblast, 143500, Russia

    B. M. Manuilov

  2. Hertzen Moscow Cancer Research Institute, National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow, 125284, Russia

    A. V. Ermakov

Authors
  1. B. M. Manuilov
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  2. A. V. Ermakov
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Correspondence to B. M. Manuilov.

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Original Russian Text © B.M. Manuilov, A.V. Ermakov, 2016, published in Biotekhnologiya, 2016, Vol. 32, No. 3, pp. 78–83.

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Manuilov, B.M., Ermakov, A.V. Preparation and Properties of Nanocolloidal Rhenium Sulfide Solution for Lymphoscintigraphic Methods of Micrometastase Examination. Appl Biochem Microbiol 53, 823–826 (2017). https://doi.org/10.1134/S000368381708004X

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  • DOI: https://doi.org/10.1134/S000368381708004X

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