Abstract
As the effective use of carbon resources has become a pressing societal issue, the importance of chemical recycling of plastics has increased. The catalytic chemical decomposition for plastics is a promising approach for creating valuable products under efficient and mild conditions. Although several commodity and engineering plastics have been applied, the decompositions of stable resins composed of strong main chains such as polyamides, thermoset resins, and super engineering plastics are underdeveloped. Especially, super engineering plastics that have high heat resistance, chemical resistance, and low solubility are nearly unexplored. In addition, many super engineering plastics are composed of robust aromatic ethers, which are difficult to cleave. Herein, we report the catalytic depolymerization-like chemical decomposition of oxyphenylene-based super engineering plastics such as polyetheretherketone and polysulfone using thiols via selective carbon–oxygen main chain cleavage to form electron-deficient arenes with sulfur functional groups and bisphenols. The catalyst combination of a bulky phosphazene base P4-tBu with inorganic bases such as tripotassium phosphate enabled smooth decomposition. This method could be utilized with carbon- or glass fiber-enforced polyetheretherketone materials and a consumer resin. The sulfur functional groups in one product could be transformed to amino and sulfonium groups and fluorine by using suitable catalysts.
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Introduction
Organic materials and products, from commodity plastics to engineering plastics and stable super engineering plastics are indispensable for society and are utilized in a variety of fields from general-purpose products to advanced materials. However, since the organic resources that comprise them are naturally finite, future societies will be required to reuse and recycle them once consumed, rather than simply dispose of them. One of the methodologies to achieve this goal is chemical recycling, i.e., the conversion of organic products into raw materials by means of organic reactions1,2,3,4,5,6,7,8,9,10,11,12,13,14. In this scenario, gasification chemical recycling of waste plastics to produce methanol, propylene, olefins, and so on is a promising method. However, gasification requires high-temperature conditions, and the resulting products must be converted back into organic raw substrates. Thus, chemical decomposition methodologies that convert plastics directly into raw organic compounds such as monomers at lower temperatures are becoming increasingly important. Especially, plastics and polymers having relatively cleavable main chains such as an ester group are useful for this purpose and are being developed. For example, chemical recycling of polyethylene terephthalate (PET) has been extensively studied, giving usable low-weight molecules15,16,17,18,19,20.
As mentioned above, many studies have developed the methodologies of the chemical decomposition of various resins, and recently, the focus is on catalytic decomposition for highly stable resins composed of strong main chains such as polyamides, polyurethanes, polyureas, thermoset resins, and super engineering plastics. For example, Nylon-6 was found to undergo decomposition in the presence of a dimethylaminopyridine21,22,23,24 or lanthanide25 catalyst to form ε-caprolactam. Catalytic hydrogenolysis was applicable to the decomposition of polyamides to produce amino alcohols26,27. Polyurethanes28,29 and polyureas30,31 were also subjected to catalytic hydrogenation to afford anilines, polyols, and amines. Decomposition of epoxy resins was developed using catalytic main-chain cleavage to provide the corresponding monomers32,33,34. Thus, the catalytic approach has the potential to achieve the decomposition of such stable resins to form useful low-weight molecules such as monomers. Among these stable resins, super engineering plastics are known for their excellent stability such as heat resistance and chemical resistance. Based on their high stability, these resins are indispensable to industries such as the automotive medical, aerospace, and other industries. However, catalytic decomposition of super engineering plastics remains nearly unexplored. A few catalytic decompositions of polyphenylenesulfide (PPS) composed of phenyl–sulfur bonds were reported to give low-molecular-weight molecules such as 1,4-dicyclopentylthiobenzene, benzene, and 1,4-dicyanobenzene (Fig. 1b)35,36,37,38. This scarcity of reports emphasizes the difficulty of catalytic decomposition of super engineering plastics. In addition, many super engineering plastics are composed of stable aromatic ethers, which are not easily cleaved.
Recently, we demonstrated that thiolate reagents are highly effective for the depolymerization-like chemical decomposition of PEEK using sulfur nucleophiles, giving monomer-like products, dithiofunctionalized benzophenones and hydroquinone (Fig. 1c)39. The electron-deficient carbonyl group in the PEEK main chain enhances the reactivity of the carbon-oxygen bond at the para position such that the highly nucleophilic thiolate reagents cleave this bond selectively. We applied this system to the chemical decomposition of PSU, PESU, and PEEK using stoichiometric amounts of CsOH·H2O and CaH2 to form the corresponding bisphenols40. We expected that these stoichiometric methods have the potential to be applied to base-catalyzed chemical decomposition of various super engineering plastics. Since the previous reactions proceeded smoothly under a moderate reaction temperature (150 °C), the proposed catalytic strategy is expected to enable equally mild transformation to provide monomer-like products in high yields. Herein, we report the catalytic depolymerization-like chemical decomposition of oxyphenylene-based super engineering plastics using thiols to form monomer-like products, dithiofunctionalized arenes, and bisphenols (Fig. 1d). This method was applicable to PEEK, PSU, PPSU, and PEI. Inorganic bases and phosphazene bases were effective catalysts for this decomposition. Since the sulfur functional group acts as a leaving group for the substitution reaction under appropriate conditions41,42, the produced dithiofunctionalized arenes could be converted into sulfonium cations followed by fluorination or aryloxylation reactions.
Results and Discussion
Optimization of the reaction conditions
We examined the chemical decomposition of insoluble polyetheretherketone (PEEK) powder (Mw ~ 20800 and Mn ~ 10300 as catalog specifications) (1) with 2-ethyl-1-hexanethiol (2a) (2 equiv. relative to monomer unit) in 1,3-dimethyl-2-imidazolidinone (DMI) under various conditions (Table 1). The decomposition was first performed using KOH, K3PO4, KOtBu, and Cs2CO3 as catalysts (10 mol% relative to monomer unit) at 150 °C to form the corresponding decomposed products, dithiobenzophenone 4a, 1,4-hydroquinone (5) and a benzophenone-hydroquinone-type dimer intermediate 3 (Table 1, Entries 1-4). The use of Cs2CO3 was especially effective to form the final decomposition monomers, 4a and 5, in good yields (Table 1, Entry 4), indicating that large counter cation sizes as well as basicity promote the decomposition. Encouraged by these results, we expected that bulky and strongly basic organic phosphazene bases such as P4-tBu (pKBH+ 30.25 in dimethylsulfoxide (DMSO))43,44,45,46,47,48 would be promising catalysts for this decomposition (Fig. 2), which enhances the nucleophilicity of the counteranions49,50,51,52,53,54,55,56,57,58,59,60,61,62,63. For example, Shigeno, Korenaga, and Kondo recently reported that P4-tBu activates an alkanethiol (pKa of n-BuSH: 17.0 in DMSO)64. In this study, highly basic phosphazene bases P4-tBu and P2-tBu (pKBH+ of P2-Et: 21.15 in DMSO) exhibited good catalytic activity in comparison with weaker bases such as DBU (pKBH+ 13.9 in DMSO) and P1-tBu-TP (pKBH+ 17.4 ± 1.2 in DMSO) (Table 1, Entries 5-8). Thus, the basicity and size of the catalysts are important for this reaction to enhance the nucleophilicity of the counter anion. Increasing the amount of 2a from 2 equiv. to 2.5 equiv. enhanced the yield of 4a and 5 (Table 1, Entry 9). On the other hand, high loading of P4-tBu (20 mol%) had little effect (see Supplementary Information, Table S1, Entry 11), suggesting that increasing the amount of P4-tBu does not directly lead to an increase in yields of 4a and 5. The P4-tBu catalyst loading was successfully reduced to 5 mol%, albeit with slightly decreased yield (Table 1, Entry 10). The reaction at lower temperatures (120 and 100 °C) decreased the yield (Table 1, Entries 11 and 12). As mentioned above, PEEK is insoluble in organic solvents, but previous studies39,40 showed that solvents affect the reactivity of the decomposition. So, we checked the solvent effects for this decomposition in detail. As a result, N,N-dimethylacetamide (DMAc) was effective in the conditions whereas other solvent such as N,N-dimethylformamide (DMF), benzonitrile (PhCN), diethylene glycol diethyl ether ((C2H5OCH2CH2)2O), and xylene decreased the yield (Table 1, Entries 13-17). P4-tBu dissolves in these solvents so that the decomposition reactivity may be affected by the polarity of the solvents53. Finally, we found that the catalyst combination of P4-tBu (10 mol%) and K3PO4 (5 mol%) enhanced the reactivity of the present decomposition and gave 4a and 5 in excellent yields in DMAc solvent (Table 1, Entry 18, see Method and section 7-1 in Supplementary Methods).
Experimental mechanistic studies
To evaluate the present catalytic decomposition reactivity, we monitored the yields of 4a and 5 during the reaction of PEEK powder 1 with 2a catalyzed by P4-tBu (10 mol%) and K3PO4 (5 mol%), P4-tBu (10 mol%), and K3PO4 (10 mol%) (Fig. 3, see section 9-1 and Table S5 in Supplementary Methods). Under the three conditions, 4a and 5 were formed after 30 minutes. Moreover, high yields of 4a and 5 were obtained after 3 h under the conditions using P4-tBu and K3PO4. These observations indicate that the decomposition proceeded rapidly. When P4-tBu catalyst was only used, decomposition proceeded faster than when K3PO4 catalyst was used. The catalyst combination of P4-tBu and K3PO4 increased the rate of formation of 4a and 5 compared to the use of P4-tBu alone. These results indicate that the use of the P4-tBu catalyst allowed for rapid decomposition. The K3PO4 assisted this catalytic activity of P4-tBu.
To understand the solvent effect for the decomposition of PEEK, we examined the swelling behavior of PEEK resins. PEEK granules or plates were heated in solvents such as DMAc, DMF, PhCN, (EtOCH2CH2)2O, and xylene at 150 °C for 19 h (See section 9-2, Table S6, and Fig. S1 in Supplementary Methods). As a result, these solvents increased the mass of the PEEK granules and plates (105~109 wt%) whereas the resins were apparently unchanged. These observations suggested that the swelling effect of PEEK does not affect the decomposition reactivity. Then we examined the reaction of 4,4’-diphenoxy-benzophenone (6) as a PEEK model compound with 2.5 equiv. of 2a and 10 mol% of P4-tBu at 150 °C for 3 h (Fig. 4a). The reaction using DMAc formed 4a and phenol in an excellent yield. On the other hand, use of other solvents such as PhCN, (C2H5OCH2CH2)2O, and xylene decreased the yield of 4a. In these cases, the reactions were not complete even after 22 h. Thus, DMAc as the high polar solvent enhanced the reactivity of the thiolate generated by the combination of the thiol and P4-tBu and probably promoted the cleavage of the carbon–oxygen bonds and the decomposition45.
Next, we carried out NMR experiments to shed light on the combination of the thiol, P4-tBu, and K3PO4. The reaction of 4-tert-butylphenylthiol (0.02 mmol) and P4-tBu (0.02 mmol) in the presence of K3PO4 (0.02 mmol) was examined in DMF-d7 (0.5 mL) at 25 °C (see section 9-3 in Supplementary Methods). As a result, a 31P{1H} NMR spectrum suggested the formation of [P4-tBu-H]+ (Fig. 4b, see Supplementary Fig. S5 compared with Fig. S2) and mass peaks were also observed at m/z 634 in ESI-TOF-(+)-MS and m/z 165 in ESI-TOF-(-)-MS mass spectra, confirming the generation of [P4-tBu-H]+·[S(C6H4-tBu)]-. The same results were observed in the absence of K3PO4 (see Supplementary Fig. S3). On the other hand, in 1H NMR spectrum, the resonances for the aryl doublets (δ 6.69 and δ 7.14) were broadened in comparison with the case in the absence of K3PO4 (Fig. 4b). In addition, these signals were different from the combination of the thiol and K3PO4 (see Supplementary Fig. S4). These results indicated that [P4-tBu-H]+·[S(C6H4-tBu)]- was initially formed and the [S(C6H4-tBu)] anion coordinated to K3PO4 in the equilibrium state. Density functional theory (DFT) calculations suggested that the NBO charge of the phenylthiolate coordinating to K3PO4 is more nucleophilic than the non-coordinating one (see section 9-4 in Supplementary Methods and Supplementary Data 2). We assumed that this catalyst combination activates the thiol for the smooth decomposition of PEEK.
Aromatic nucleophilic substitution with thiolate anions is known to proceed via the SNAr or SRA1 mechanism65,66,67. In the SRA1 mechanism, thiyl radicals are thought to be involved. However, this catalytic decomposition of PEEK gives hydroquinone which inhibits the generation of free radicals. We examined the decomposition with 2a under P4-tBu/K3PO4 catalyst with 3,5-di-tert-butyl-4-hydroxytoluene (BHT, 2.5 equiv.), a radical inhibitor, at 150 °C for 16 h and observed the formation of 4a and 5 in high yields (Fig. 4c). These results ruled out the possibility of a radical pathway for the decomposition. Of note, 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) as a typical radical scavenger was not suitable for this experiment, which converted 2a into the corresponding disulfide in the absence of PEEK (see section 9-5 and Table S7, S8 in Supplementary Methods)68.
Proposed mechanism
A plausible pathway for the chemical decomposition catalyzed by P4-tBu and K3PO4 is shown in Fig. 5. The thiol is initially activated by P4-tBu to form a thiolate that interacts with K3PO4 in the equilibrium state. The sulfur center of the thiolate attacks the ipso-carbon bound to oxygen in the benzophenone unit in PEEK to form an anionic intermediate. The aryloxy anion is released to complete carbon–sulfur bond formation. K3PO4 may enhance the reactivity of the thiolate and assist in the release of the aryloxy anion. The generated aryloxy anion activates the thiol to form the organic thiolate and arenols. In fact, the basicity of arenols (pKa in DMSO of PhOH: 18.0; p-MeC6H4OH: 18.9)69 is higher than that of thiols (pKa in DMSO of n-BuSH: 17.0; PhSH: 10.3)64. This series of processes occurs repeatedly to generate the dithiobenzophenone 4 and hydroquinone (5).
Substrate scope
With the optimum conditions using both P4-tBu and K3PO4 in hand, we examined the chemical decomposition of other super engineering plastics such as polysulfone (PSU), polyetherethersulfone (PEES), polyphenylsulfone (PPSU), polyethersulfone (PESU), and polyetherimide (PEI) which were analyzed by high-temperature GPC analysis prior to use (see section 9-6 and Table S9 in Supplementary Methods). These resins have cleavable aryl-oxygen bonds affected by electron-withdrawing groups in a manner similar to PEEK. PSU is composed of diphenylsulfone and bisphenol A. Since thiolate anions can cleave aryl-SO2 bonds70,71,72,73,74, we were concerned that the present catalytic method may cleave the aryl-SO2 bond in the diphenylsulfone unit as well as the target C–O main chain. However, we found that polysulfone (PSU) pellets 7 (purchased from Sigma-Aldrich) and 7’ (purchased from Acros Organics) with different Mw (Mw 35000 and Mw 60000) in each of the catalog specifications underwent the decomposition with 2a via selective C–O bond cleavage38 to furnish the corresponding 4,4’-dialkylthiobenzosulfone (8a) and bisphenol A (9) in high yields (Table 2, Entries 1 and 2). In addition, there was no clear difference in the reaction rate between 7 and 7’ (see Supplementary Table S2). In the same way, PEES pellets (10) or PPSU powder (11) could be converted into 8a and hydroquinone (5) or 4,4’-dihydroxybiphenyl (12) in high yields (Table 2, Entries 3 and 4). In the case of PESU (13) consisting of repeating oxy-diphenylsulfone units, three products 8a, 4-alkylthio-4’-hydroxy-diphenylsulfone 14, and bisphenol S (15) were obtained (Table 2, Entry 5). PEI is composed of repeating structures of phenylene-1,3-bisphthalimide and bisphenol A. In this case, imide bonds in the phthalimide units may be cleaved by sulfur nucleophiles75. Nevertheless, the C–O main chains were successfully cleaved selectively in the decomposition of PEI pellets 16 with 2a, giving dithiofunctionalized phenylene-1,3-bisphthalimide 17 and 9 in good yields (Table 2, Entry 6).
We then explored the scope of thiols under the catalytic decomposition of PSU pellets 7 (Fig. 6). 2-Phenylethanethiol or 2-mercaptoethanol underwent decomposition at 100 °C to form 8b (see section 7-2 in Supplementary Methods) or 8c and bisphenol A (9) in good yields. Triethoxysilyl-substituted propanethiol and cyclopentanethiol were used in the decomposition and the corresponding decomposition products 8d and 8e were obtained. Trimethylsilylmethylthiol gave 4,4’-dimethylthiodiphenylsulfone 8f and 9 in high yields via desilylation. Not only alkanethiols but also 4-tert-butylbenzenethiol could be utilized for decomposition with only NaOtBu catalyst (20 mol%) to form the corresponding monomer 8g in 98% yield together with 9 quantitatively (see Supplementary Table S3 and section 7-3 in Supplementary Methods)). Instead of PSU, we attempted the decomposition of PEEK powder with 4-tert-butylbenzenethiol under the P4-tBu/K3PO4 or NaOtBu catalyst in DMAc but the yield of the product, 4,4’-di(arylthiol)benzophenone 4b, was low (see Supplementary Table S4 and section 7-4 in Supplementary Methods). At that time, a suspension containing precipitated 4b and its intermediates were obtained. Considering that the poor solubility of the products may have decreased the reactivity, we modified the conditions using a P4-tBu/Cs2CO3 catalytic combination in DMI to enhance the solubility. As a result, 4b was obtained in high yield, albeit with a long reaction time.
Utility of the decomposition method
To demonstrate the scalability of the decomposition method, a gram-scale reaction of PSU pellets (7) with cyclopentanethiol catalyzed by 5 mol% of P4-tBu and K3PO4 was carried out. The desired products 8e and 9 were isolated in 78% and 75% yields, respectively (Fig. 7a, see section 7-5 in Supplementary Methods). It is worth noting that this catalytic method was applicable to composite materials. Shaved powder of 30 wt% carbon-fiber reinforced PEEK (1’) underwent the decomposition with 2a to form 4a and 5 in good yields comparable to those obtained from neat PEEK powder (Fig. 7b, see section 7-6 in Supplementary Methods). 30 wt% Glass-fiber reinforced PEEK (1’’’) was converted into 4a and 5 in the same way. In addition, small pieces of a baby bottle made up of PPSU (11’) as a representative consumer resin were transformed into products, 8a and 12, in high yields (see section 7-7 in Supplementary Methods).
Utility of products
Sulfur functional groups in the products can be utilized in various transformations to yield functional molecules. For example, 8e was applicable to the double cross-coupling with 4-decylaniline under palladium-catalyzed conditions76 to give the corresponding double amination product 18 (Fig. 8a, see section 7-8 in Supplementary Methods). Double phenylation of 4b using diphenyliodonium trifluoromethanesulfonate and copper acetate catalyst in 1,2-dichloroethane at 100 °C, based on a reported method77, gave benzophenone 4,4′-bis(diarylsulfonium) salt 19 in excellent yield (Fig. 8b, see section 7-9 in Supplementary Methods). Such sulfonium groups are more reactive leaving groups than their parent sulfur functional groups. Thus, the sulfonium groups in 19 could be converted into fluorine by potassium fluoride and Kryptofix® 222 (4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) in N,N-dimethylformamide at 60 °C (see section 7-10 in Supplementary Methods)78. Of note, the product, 4,4’-difluorobenzophenone (20), is used as a monomer for PEEK79,80. PSU-depolymerized product 8g was also applicable to this transformation sequence. Double phenylation of 8g afforded diphenylsulfone 4,4′-bis(diarylsulfonium) salt 21 (Fig. 8c, see section 7-11 in Supplementary Methods). Subsequent fluorination of 21 gave bis(4-fluorophenyl)sulfone (22) in 87% yield (see section 7-12 in Supplementary Methods), which is a monomer of diphenylsulfone-based polymers such as PSU81,82, PPSU83,84,85,86,87,88,89,90, PESU91,92, and PEES93. In addition, 21 reacted with p-methoxyphenol in the presence of Cs2CO3 to give 4,4’-bis(p-anisyloxy)diphenylsulfone (23) in 79% yield (see section 7-13 in Supplementary Methods).
Conclusion
In this study, we demonstrated that the depolymerization-like chemical decomposition of robust super engineering plastics such as PEEK, PSU, PEES, PPSU, PESU, and PEI occurred smoothly with thiols at moderate temperature under the catalytic combination of bulky organic super bases, P4-tBu, and inorganic bases, K3PO4 or Cs2CO3. DMAc solvent also promoted the carbon-oxygen bond cleavages in a low-weight molecule and insoluble PEEK due to its polarity under the conditions. Various thiols were applied to this decomposition to afford monomer-like thiofunctionalized arenes and bisphenols in high yields. In addition, carbon fiber- or glass fiber-reinforced resins and a baby bottle made of PPSU as a representative consumer resin material were utilized in this catalytic decomposition. From a synthetic perspective, thiofunctionalities in the arene products act as leaving groups and can be transformed into various substituents such as amino groups and fluorine. Notably, fluorinated arenes are parent monomers for synthesizing super engineering plastics. This shows that the present catalytic decomposition method can be utilized not only for chemical recycling but also for upcycling. This development will expand the decomposition of other robust polymer materials with various reagents under this effective catalytic system.
Methods
General procedure for catalytic chemical decomposition of PEEK
To a mixture of PEEK powder (28.8 mg, 0.100 mmol relative to the molecular weight of the monomer), and potassium phosphate tribasic (1.1 mg, 0.0050 mmol) was added N,N-dimethylacetamide (0.20 mL), P4-tBu phosphazene base in hexane solution (1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)-phosphoranylidenamino]-2λ5,4λ5-catenadi(phosphazene), 0.8 M, 0.0125 mL, 0.010 mmol), and 2-ethylhexanethiol (36.6 mg, 0.250 mmol) in a 3 mL vial under argon atmosphere. The resultant mixture was stirred at 150 °C for 16 h. The reaction mixture was cooled to room temperature. The mixture was analyzed by 1H NMR in acetone-d6 to determine the yields of the products, 4a and hydroquinone (5), using 1,4-dioxane as an internal standard. The reaction mixture was concentrated in vacuo. The crude product was purified by column chromatography on silica gel (hexane/ethyl acetate 96:4 to 7:3) to give bis(4-(2-ethylhexylthio)phenyl)methanone (85%, 39.9 mg) and 1,4-hydroquinone (61%, 6.7 mg).
General information. See Supplementary Methods, general information (page S3).
Chemicals. See Supplementary Methods, chemicals (page S3).
NMR charts. See Supplementary Data 1, NMR spectra of obtained chemicals.
Data availability
The data obtained in this study are available within this article and its supplementary information and are also from the corresponding authors upon reasonable request. Original 1H and 13C spectra of the compounds obtained in this manuscript are available in Supplementary Data 1. The computed energy values and coordinates are available in Supplementary Data. 2.
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Acknowledgements
This work was supported financially by PRESTO (JPMJPR21N9 to Y.M.) from the JST, Iketani Science and Technology Foundation, Tobe Maki Scholarship Foundation, Grants-in-Aid for Scientific Research (C) (19K05481 to Y.M.) from the JSPS, and Department of Materials and Chemistry, AIST. Y.M., N.M., and Y.N. also acknowledge the DIC Corporation. Y.M. would like to thank Dr. Masanori Shigeno for discussions about the catalytic activity. Y.M would like to thank JST, ERATO (JPMJER2103), and Prof. Kyoko Nozaki and her lab members, Prof. Kohei Takahashi, Prof. Takanori Iwasaki, Prof. Shuhei Kusumoto, and Prof. Xiongjie Jin, for their discussions on this project. We would like to thank Ms. Risa Kawato for her assistance in the high-temperature GPC analysis.
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Y.M. conceived the idea and designed the whole experiment with S.I. and N.M. Y.M., S.I., and N.M. performed the experiments. Y.M., S.I., and N.M. contributed to writing the manuscript and participated in data analyses and discussions. S.I. and N.M. contributed equally to this paper. Y.M. performed the DFT calculations. Y.N. and M.Y. supported this project. Y.M. revised the paper.
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Minami, Y., Imamura, S., Matsuyama, N. et al. Catalytic thiolation-depolymerization-like decomposition of oxyphenylene-type super engineering plastics via selective carbon–oxygen main chain cleavages. Commun Chem 7, 37 (2024). https://doi.org/10.1038/s42004-024-01120-7
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DOI: https://doi.org/10.1038/s42004-024-01120-7
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