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Haploidentical hematopoietic stem cell transplantation with αβTCR+/CD19+ depletion in pediatric patients with malignant and non-malignant disorders

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Abstract

Haploidntical hematopoietic stem cell transplantation has been increasingly used in recent years for patients without a matched donor. The αβTCR+/CD19+ depletion technique provide a graft that is enriched with CD34 cells, γδ-T-cells and natural killer. The current experience with αβTCR+/CD19+ depleted grafts in pediatric patients with malignant and non-malignant disorders, demonstrated rapid engraftment, improved immune reconstitution and low risk of GVHD. Future studies will need to define the optimal conditioning regimen in order to improve transplant outcome.

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Funding

Publication of this supplement was sponsored by Gilead Sciences Europe Ltd, Cell Source, Inc., The Chorafas Institute for Scientific Exchange of the Weizmann Institute of Science, Kiadis Pharma, Miltenyi Biotec, Celgene, Centro Servizi Congressuali, and Almog Diagnostic.

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Authors and Affiliations

  1. Department of Pediatric Hematology-Oncology & BMT, The Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Ramat-Gan, Israel

    Bella Bielorai, Elad Jacoby, Daphna Hutt, Chaim Churi & Amos Toren

  2. Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Bella Bielorai, Elad Jacoby & Amos Toren

  3. Institute of Hematology, Sheba Medical Center, Ramat-Gan, Israel

    Nira Varda-Bloom & Helly Vernitsky

Authors
  1. Bella Bielorai
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  2. Elad Jacoby
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  3. Nira Varda-Bloom
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  4. Daphna Hutt
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  5. Chaim Churi
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  6. Helly Vernitsky
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  7. Amos Toren
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Corresponding author

Correspondence to Bella Bielorai.

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Conflict of interest

EJ has received lecture fees from Novartis Israel and received support from the Dotan grant for Hematologic Malignancies. The authors declare that they have no conflict of interest.

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Bielorai, B., Jacoby, E., Varda-Bloom, N. et al. Haploidentical hematopoietic stem cell transplantation with αβTCR+/CD19+ depletion in pediatric patients with malignant and non-malignant disorders. Bone Marrow Transplant 54 (Suppl 2), 694–697 (2019). https://doi.org/10.1038/s41409-019-0607-0

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