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Outcome of extremely low birth weight (ELBW) infants from a birth cohort (2013–2018) in a tertiary care unit in North India

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Abstract

Objective

To evaluate mortality and short-term morbidities in extremely low birth weight (ELBW) infants (<1000 g) in a birth cohort in North India.

Methods

In-hospital data of 231 ELBW infants (Jan 2013 to Sept 2018) were collected from a prospectively maintained electronic database by using standard definitions.

Results

The mean (SD) gestation and birth weight were 27.9 (2.2) weeks and 783 (133) g, respectively. Major morbidities included respiratory distress syndrome (n = 132, 57%), moderate-to-severe bronchopulmonary dysplasia (n = 62, 26.8%), hemodynamically significant patent ductus arteriosus (n = 65, 28%), intracranial hemorrhage ≥ grade II (n = 38, 16%), and culture-positive sepsis (n = 44, 19%). Median (IQR) duration of hospital stay (survivors) was 50 (17–79) days. The overall survival was 62%. On logistic regression, severe birth asphyxia, gestation ≤26 weeks, and respiratory distress syndrome were major predictors of mortality.

Conclusion

In the current ELBW cohort, nearly two-thirds survived until discharge, who had considerable morbidities needing prolonged hospital stay. This study can be utilized for counseling and planning of care of ELBW infants in similar settings.

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Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India

    Tanushree Sahoo, Pratima Anand, Ankit Verma, Manju Saksena, Mari Jeeva Sankar, Anu Thukral, Ramesh Agarwal, Ashok Deorari & Vinod K. Paul

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  1. Tanushree Sahoo
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  2. Pratima Anand
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  3. Ankit Verma
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  4. Manju Saksena
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  5. Mari Jeeva Sankar
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  6. Anu Thukral
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  7. Ramesh Agarwal
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Contributions

TS and PA collected the data, did preliminary analysis, and wrote the first draft of the paper. AV, AT, RA, AD, MJS, and VKP contributed in writing the paper and providing critical feedback. MS contributed in writing the paper, validation of data and cross checking. She is the guarantor of the final paper. TS and MJS analyzed the data. All the authors approved the final version of the paper as submitted.

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Correspondence to Manju Saksena.

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The authors declare that they have no conflict of interest.

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Sahoo, T., Anand, P., Verma, A. et al. Outcome of extremely low birth weight (ELBW) infants from a birth cohort (2013–2018) in a tertiary care unit in North India. J Perinatol 40, 743–749 (2020). https://doi.org/10.1038/s41372-020-0604-6

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  • DOI: https://doi.org/10.1038/s41372-020-0604-6

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