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Sucrose vs. skin to skin care for preterm neonatal pain control—a randomized control trial

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Abstract

Objective

To compare the efficacy of SSC with oral Sucrose for pain management in preterm neonates.

Methodology

Parallel-group, assessor-blinded randomized control trial conducted from February-June 2017 at a level 3B-NICU. Hundred preterm neonates (29-0/7 to 36-6/7 weeks gestational age) requiring heel-stick were randomly assigned (1:1), to SSC (50, Group-A) and Sucrose (50, Group-B). In Group-A, SSC was provided at least 10 min before the procedure. In Group-B, 0.2 ml of oral Sucrose was provided 2 min before the procedure. Blinded assessment of Premature Infant Pain Profile (PIPP) score was done 30 s post-procedure using recorded videos.

Results

Baseline variables were [Mean(SD)] gestational age [32.79(2.34) weeks], age [14.04(11.10) days] and birth weight [1.62(0.35) kilograms]. PIPP score was less in group- A vs. B but could not achieve statistical significance [Mean(SD): 7.74(2.43) vs. 8.1(2.82), p = 0.50 CI of the difference: (−1.40,0.68)].

Conclusions

SSC and Sucrose have comparable efficacy in managing pain in premature neonates.

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Author contributions:

Dr. VS-conceptualized and planned the study, drafted the proposal and manuscript, planned and oversaw data collection, revised the manuscript and consented to the final manuscript as submitted. Dr. AC contributed to data collection, analysis of study, drafting the manuscript and consented to the final manuscript. Dr. JU contributed to data collection, analysis of study, and consented to the final manuscript. Dr. AN conceptualized and devised the study, analyzed the data, contributed to manuscript writing, and consented to the final manuscript. Mr. AP contributed to study design, analyzed the data, provided important intellectual inputs to the manuscript, and consented to the final manuscript submitted. Dr. SN conceptualized, planned, and supervised the progress of the study, analyzed the data, provided important intellectual inputs to the manuscript, revised the manuscript, and consented to the final manuscript as submitted. He will be the guarantor for the study.

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Authors and Affiliations

  1. SUNY, Downstate Medical Center, Brooklyn, NY, USA

    Vivek Shukla

  2. Pramukhswami Medical College, Gujarat, India

    Apurva Chapla, Jigar Uperiya, Archana Nimbalkar & Somashekhar Nimbalkar

  3. Charutar Arogya Mandal, Gujarat, India

    Ajay Phatak

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  1. Vivek Shukla
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  2. Apurva Chapla
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  6. Somashekhar Nimbalkar
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Correspondence to Vivek Shukla.

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Shukla, V., Chapla, A., Uperiya, J. et al. Sucrose vs. skin to skin care for preterm neonatal pain control—a randomized control trial. J Perinatol 38, 1365–1369 (2018). https://doi.org/10.1038/s41372-018-0193-9

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