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Rab1 in cell signaling, cancer and other diseases

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Abstract

The endoplasmic reticulum (ER) and Golgi membrane system have major roles in cell signaling and regulation of the biosynthesis/transport of proteins and lipids in response to environmental cues such as amino acid and cholesterol levels. Rab1 is the founding member of the Rab small GTPase family, which is known to mediate dynamic membrane trafficking between ER and Golgi. Growing evidence indicate that Rab1 proteins have important functions beyond their classical vesicular transport functions, including nutrient sensing and signaling, cell migration and presentation of cell-surface receptors. Moreover, deregulation of RAB1 expression has been linked to a myriad of human diseases such as cancer, cardiomyopathy and Parkinson’s disease. Further investigating these new physiological and pathological functions of Rab1 should provide new opportunities for better understanding of the disease processes and may lead to more effective therapeutic interventions.

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Acknowledgements

Related work in authors’ laboratories was supported by NIH R01 grants CA123391, CA166575 and CA173519, the National Natural Science Foundation of China, grant nos: 81171891, 81270035 and 81572440, the Recruitment Program of Global Experts, the Lead Talent of Guangdong Province, the Natural Science Foundation of Guangdong Province for Distinguished Young Scholar (no: 2015A030306047), the Research Fund of State Key Laboratory of Oncology in South China, and Shanghai Pujiang Program 15PJ1404900.

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Authors and Affiliations

  1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China

    X-Z Yang, X-X Li, H-Y Wang & X F S Zheng

  2. Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA

    Y-J Zhang, L Rodriguez-Rodriguez, H-Y Wang & X F S Zheng

  3. Oncology Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

    Y-J Zhang

  4. Department of Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA

    L Rodriguez-Rodriguez

  5. and Department of Pediatrics, Center for Advanced Biotechnology and Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA

    M-Q Xiang

  6. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

    M-Q Xiang

  7. Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA

    H-Y Wang & X F S Zheng

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  1. X-Z Yang
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Yang, XZ., Li, XX., Zhang, YJ. et al. Rab1 in cell signaling, cancer and other diseases. Oncogene 35, 5699–5704 (2016). https://doi.org/10.1038/onc.2016.81

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