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Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats

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Abstract

Background

We aimed to evaluate the effect of doxylamine, a first generation antihistamine, as a local analgesic agent by comparing its effect to bupivacaine.

Methods

After blocking the cutaneous trunci muscle reflex (CTMR) by subcutaneous injection of doxylamine, we assessed doxylamine’s cutaneous analgesic effect in rats. The dose-related effect and duration of doxylamine on infiltrative cutaneous analgesia were compared with that of bupivacaine.

Results

We demonstrated that doxylamine, as well as the local anesthetic bupivacaine produced the cutaneous analgesic effects in a dose-related fashion. At the equipotent dose (50% effective doses (ED50)), the relative potency was bupivacaine (0.41 (0.36–0.48) mmol)> doxylamine (7.39 (6.91–7.91) mmol) (p < 0.01). On an equipotent basis (ED25, ED50 and ED75), subcutaneous doxylamine resulted in greater duration of action (p < 0.01) than bupivacaine at producing cutaneous analgesia.

Conclusions

The result of this experiment indicated that doxylamine has the local anesthetic property less potent than bupivacaine, but its nociceptive block duration is longer than that of bupivacaine at an equianalgesic dose.

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Authors and Affiliations

  1. Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Ching-Hsia Hung

  2. Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Ching-Hsia Hung

  3. Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan

    Ja-Ping Shieh

  4. Center for General Education, Southern Taiwan University of Science and Technology, Tainan, Taiwan

    Ja-Ping Shieh

  5. Department of General Surgery, Chi Mei Medical Center, Tainan and Liouying, Taiwan

    Chong-Chi Chiu

  6. Department of Electrical Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan

    Chong-Chi Chiu

  7. Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan

    Jhi-Joung Wang & Yu-Wen Chen

  8. Department of Physical Therapy, College of Health Care, China Medical University, Taichung, Taiwan

    Yu-Wen Chen

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  1. Ching-Hsia Hung
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  2. Ja-Ping Shieh
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  3. Chong-Chi Chiu
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  4. Jhi-Joung Wang
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  5. Yu-Wen Chen
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Correspondence to Yu-Wen Chen.

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Hung, CH., Shieh, JP., Chiu, CC. et al. Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats. Pharmacol. Rep 70, 565–569 (2018). https://doi.org/10.1016/j.pharep.2017.12.006

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  • DOI: https://doi.org/10.1016/j.pharep.2017.12.006

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