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Effects of fenoterol on the skeletal system depend on the androgen level

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Abstract

Background

The role of sympathetic nervous system in the osseous tissue remodeling is not clear enough.

Methods

The effects of fenoterol, a selective β2-adrenomimetic drug, on the skeletal system of normal and androgen deficient (orchidectomized) rats were studied in vivo. Osteoclastogenesis and mRNA expression in osteoblasts were investigated in vitro in mouse cell cultures.

Results

Fenoterol administered to animals with physiological androgen level unfavorably affected the skeletal system, damaging the bone microarchitecture. Androgen deficiency induced osteoporotic changes, and fenoterol protected the osseous tissue from consequences of androgen deficiency. The results of in vitro studies correlated with the in vivo observations. A significantly increased number of osteoclasts in bone marrow cell cultures to which testosterone and fenoterol were added simultaneously was demonstrated. In cultures without the addition of testosterone, fenoterol significantly inhibited osteoclastogenesis in comparison with control cultures.

Conclusions

The results indicate the favorable action of fenoterol in conditions of testosterone deficiency, and its destructive influence upon the skeleton in the presence of androgens. The results confirm the key role of sympathetic nervous system in the regulation of bone remodeling.

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Authors and Affiliations

  1. Department of Pharmacology School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Katowice, Poland

    Leszek Śliwiński, Urszula Cegieła, Maria Pytlik, Joanna Folwarczna, Aleksandra Janas & Małgorzata Zbrojkiewicz

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  1. Leszek Śliwiński
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  2. Urszula Cegieła
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  3. Maria Pytlik
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Correspondence to Leszek Śliwiński.

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Śliwiński, L., Cegieła, U., Pytlik, M. et al. Effects of fenoterol on the skeletal system depend on the androgen level. Pharmacol. Rep 69, 260–267 (2017). https://doi.org/10.1016/j.pharep.2016.09.023

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  • DOI: https://doi.org/10.1016/j.pharep.2016.09.023

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