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Coenzyme Q10 — A new player in the treatment of heart failure?

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Abstract

Coenzyme Q10 is the only endogenously synthesized lipid with a redox function which exhibits broad tissue and intracellular distribution in mammals. Beneficial effects of Coenzyme Q10 supplementation were observed in several age-related diseases including heart failure. CoQ10 (coenzyme Q10) level is significantly decreased in patients with this disease, which correlates with severity of clinical symptoms. Supplementation with various pharmaceutical formulations of CoQ10 improves impaired cardiac function and clinical course of heart failure. Current data from clinical trials indicate that CoQ10 can significantly reduce morbidity and mortality of heart failure patients in addition to guideline recommended pharmacotherapy.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Poznan University of Medical Sciences, Poznań, Poland

    Jerzy Jankowski, Katarzyna Korzeniowska, Artur Cieślewicz & Anna Jabłecka

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  1. Jerzy Jankowski
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  2. Katarzyna Korzeniowska
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  3. Artur Cieślewicz
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Correspondence to Artur Cieślewicz.

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Jankowski, J., Korzeniowska, K., Cieślewicz, A. et al. Coenzyme Q10 — A new player in the treatment of heart failure?. Pharmacol. Rep 68, 1015–1019 (2016). https://doi.org/10.1016/j.pharep.2016.05.012

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