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Odors identification differences in deficit and nondeficit schizophrenia

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Abstract

Background

There is evidence that deficit schizophrenia (DS) is associated with neuroanatomical changes in structures including those involved in olfaction. Olfactory dysfunction, which includes impaired odor identification, is found in patients with schizophrenia and their family members.

Methods

82 patients with DS and 72 patients with NDS (nondeficit schizophrenia), somatically healthy and without acute psychotic symptoms undertook a smell identification test using the 16-item Sniffin’ Sticks ID test. Demographic and psychometric data were collected.

Results

No differences in the course of the illness, perinatal history and demographic data were found between the DS and NDS groups. No differences in the number of correctly identified odor samples were found. Some differences in the qualitative identification of samples between DS and NDS were found in the groups of female (fewer correct identifications of cinnamon and pineapple smells in DS) and male patients (fewer correct identifications of the smell of rose and more correct identifications of the smell of orange than in NDS).

Conclusions

No overall differences between DS and NDS regarding odors identification have been found. The results seem to indicate some specific deficits in the identification of markers of rose, pineapple, orange and cinnamon.

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Abbreviations

ALT:

alanine transaminase

AST:

aspartate transaminase

CNS:

central nervous system

DS:

deficit schizophrenia

DSM IV:

Diagnostic and Statistical Manual of Mental Disorders, Forth Edition

DUP:

duration of untreated psychosis

GABA:

γ-aminobutyric acid

ICD10:

International Statistical Classification of Diseases and Related Health Problems, Tenth Edition

MINI:

Mini International Neuropsychiatric Interview

NDS:

non deficit schizophrenia

OPCRIT:

Operational Criteria for Psychotic Illness

PANSS:

Positive and Negative Syndrome Scale

SDS:

Schedule for the Deficit Syndrome

S’S:

Sniffin Sticks

TSH:

thyroid-stimulating hormone

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Authors and Affiliations

  1. Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland

    Justyna Pełka-Wysiecka, Michał Wroński & Jerzy Samochowiec

  2. Department of Pharmacology, Institute of Psychiatry and Neurology, Warszawa, Poland

    Przemysław Bieńkowski

  3. Dialogue Therapy Centre, Warszawa, Poland

    Sławomir Murawiec

  4. Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Szczecin, Poland

    Agnieszka Samochowiec

Authors
  1. Justyna Pełka-Wysiecka
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  2. Michał Wroński
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Correspondence to Jerzy Samochowiec.

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Pełka-Wysiecka, J., Wroński, M., Bieńkowski, P. et al. Odors identification differences in deficit and nondeficit schizophrenia. Pharmacol. Rep 68, 390–395 (2016). https://doi.org/10.1016/j.pharep.2015.11.001

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  • DOI: https://doi.org/10.1016/j.pharep.2015.11.001

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