Abstract
Guavira fruits have antimicrobial, antioxidant, antinociceptive, and anti-inflammatory activities. Spray drying has been widely used in the food industry presenting good retention in bioactive compounds used to transform the pulp/fruit juice into powder form. Therefore, the present study has evaluated the antiinflammatory and antinociceptive activities of the microencapsulated pulp of Campomanesia adamantium (Cambess.) O.Berg, Myrtaceae, by spray drying. Different groups of mice were treated with the doses of 100 and 300 mg/kg of microencapsulated “guavira” pulp and inflammatory parameters were assessed in a carrageenan paw edema-model and leukocyte migration with pleurisy model, while the antinociceptive activity was assessed using the formalin method and CFA-induced hyperalgesia model. A significant reduction in leukocyte migration and in paw edema was observed in rodents in all time after carrageenan injection for both doses of microencapsulated pulp of C. adamantium when compared with control group. Microencapsulated pulp of C. adamantium also reduced licking time at the first (nociceptive) and second (inflammatory) phases in the formalin model. In CFA-induced cold and mechanical hyperalgesia, depressive behavior, and knee edema, all parameters analyzed were significantly inhibited by microencapsulated pulp of C. adamantium. Microencapsulation by spray drying proved to be a technique that promotes bioavailability and the preservation of bioactive components in guavira pulp.
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Aquino, D.F.S., Piccinelli, A.C., Soares, F.L., Arena, A.C., Salvador, M.J., Kassuya, C.A., 2015. Anti-hyperalgesic and anti-inflammatory activity of alternanthera mar-itima extract and 2″-O-α-L-rhamnopyranosylvitexin in mice. Inflammation 1, 1–10.
AOAC., 2000. Official Methods of Analysis of AOAC International. Association of Official Analytical Chemists. AOAC., Maryland.
Breda, C.A., Sanjinez-Argandoña, E.J., Correia, C.A.C., 2012. Shelf life of powdered Campomanesia adamantium pulp in controlled environments. Food Chem. 135, 2960–2964.
Cabrera, M., Simoens, M., Falchi, G., Lavaggi, M.L., Piro, O.E., Castellano, E.E., 2007. Synthetic chalcones, flavanones, and flavones as antitumoral agents: biological evaluation and structure-activity relationships. Bioorg. Med. Chem. 15, 3356–3367.
Cardoso, C.A., Salmazzo, G.R., Honda, N.K., Prates, C.B., Vieira, M.C., Coelho, R.G., 2010. Antimicrobial activity of the extracts and fractions of hexanic fruits of Campomanesia species (Myrtaceae). J. Med. Food 13, 1273–1276.
Chen, Q., Zhou, Y., Liu, X., Wu, X., Chen, R., 2014. Multi-objective optimization of spray drying of jujube (Zizyphus jujuba Miller) powder using response surface methodology. Food Bio process Technol. 7, 1807–1818.
Coutinho, I.D., Cardoso, C.A.L., Ré-Poppi, N., Melo, A.M., Vieira, M.C., Honda, N.K., Coelho, R.G., 2009. Gas Chromatography-Mass Spectrometry (GC-MS) evaluation of antioxidant and antimicrobial activities of essential oil of Campomanesia adamantium (Cambess.) O Berr. (Guavira). Braz. J. Pharm. Sci. 45, 767–776.
Coutinho, I.D., Coelho, R.G., Kataoka, V.M.G., Honda, N.K., Silva, J.R.M., Vilegas, W., 2008. Determination of phenolic compounds and evaluation of antioxidant capacity of Campomanesia adamantium leaves. Eclet. Quim. 33, 53–60.
Coutinho, I.D., Kataoka, V.M.G., Honda, N.K., Coelho, R.G., Vieira, M.C., Cardoso, C.A.L., 2010. Influênciada variacão sazonal nos teores de flavonóides e atividade antiox-idante das folhas de Campomanesia adamantium (Cambess.) O. Berg, Myrtaceae. Rev. Bras. Farmacogn. 20, 322–327.
Dewick, P.M., 2005. Medicinal Natural Products: A Biosynthetic Approach. John Wiley & Sons, England.
Djeridane, A., Yousfi, M., Nadjemi, B., Boutassouna, D., Stocker, P., Vidal, N., 2006. Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food Chem. 97, 654–660.
Fernandes, T.O., Ávila, R.I., Moura, S.S., Ribeiro, G.M., Naves, M.M.V., Valadares, M.C., 2014. Campomanesia adamantium (Myrtaceae) fruits protect HEPG2 cells against carbon tetrachloride-induced toxicity. Toxicol. Rep. 2, 184–193.
Ferreira, L.C., Grabe-Guimarães, A., de Paula, C.A., Michel, M.C.P., Guimarães, R.G., Rezende, S.A., Filho, J.D.S., Saúde-Guimarães, D.A., 2013. Anti-inflammatory and antinociceptive activities of Campomanesia adamantium. J. Ethnopharmacol. 145, 100–108.
Harbone, J.B., 1994. The Flavonoids-advances in Research Since 1986. Chapman & Hall, London.
Hodek, P., Trefil, P., Stiborová, M., 2012. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem. Biol. Interact. 139, 1–21.
Kassuya, C.A., Cremoneze, A., Barros, L.F., Simas, A.S., Lapa, F. da R., Mello-Silva, R., Stefanello, M.E., Zampronio, A.R., 2009. Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovate (Magnoliaceae). J. Ethnopharmacol. 124, 369–376.
Lescano, C.H., Iwamoto, R.D., Sanjinez-Argandon, E.J., 2014. Diuretic and anti-inflammatory activities of the microencapsulated acrocomia aculeata (Are-caceae) oil on Wistar rats. J. Med. Food 18, 656–662.
Lorenzi, H., 2000. Árvores Brasileiras: Manual de Identificacão e Cultivo de Plantas Arbóreas Nativas do Brasil. Instituto Plantarum, Nova Odessa.
Mahdavi, S.A., Jafari, S.M., Ghorbani, M., Assadpoor, E., 2014. Spray-drying microencapsulation of anthocyanins by natural biopolymers: a review. Dry Technol. 32, 509–518.
Nowakowska, Z., 2007. A review of anti-infective and anti-inflammatory chalcones. Eur. J. Med. Chem. 42, 125–137.
Oliveira, V.S., Sanjinez-Argandona, E.J., Alves, A.V., 2014. Retention of vitamin C in microencapsulated Guavira pulp by spray drying. Revista Facultad Nacional de Agro 67, 202–204.
Pascoal, A.C.R.F., Ehrenfried, C.A., Lopez, B.G.C., Arauj, T.M., Pascoal, V., Gilioli, R., Pavan, F.R., Leite, C.Q.F., Coelho, R.G., Coutinho, I.D., Honda, N.K., Cardoso, C.A.L., 2014. Antiproliferative activity and induction of apoptosis in PC-3 cells by the chalcone cardamonin from Campomanesia adamantium (Myrtaceae) in a bioactivity-guided study. Molecules 19, 1843–1855.
Pavan, F.R., Leite, C.Q.F., Coelho, R.G., Coutinho, I.D., Honda, N.K., Cardoso, C.A.L., et al., 2009. Evaluation of anti-mycobacterium tuberculosis activity of Campomanesia adamantium(Myrtaceae). Quim Nova 32, 1222–1226.
Piccinelli, A.C., Santos, J.A., Konkiewitz, E.C., Oesterreich, S.A., Formagio, A.S.N., Croda Julio Ziff, E.B., Kassuya, C.A.L., 2015. Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, a-phellandrene, and essential oil from Schinus terebinthi-folius fruits in a neuropathic pain model. Nutr. Neurosci. 18, 217–224.
Rahman, M.A., 2012. Chalcone: a valuable insight into the recent advances and potential pharmacological activities. Chem. Sci. J. 29, 1–16.
Ramos, D.D., Cardoso, C.A.L., Yamamoto, N.T., 2007. Avaliacão do potencial citotóx-ico e atividade antioxidante em Campomanesia adamantium (Cambess.) O. Berg (Myrtaceae). Rev. Bras. Biocienc. 5, 774–776.
Raygude, K.S., Kandhare, A.D., Ghosh, P., Ghule, A.E., Bodhankar, S.L., 2012. Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. Inflammopharmacology 20, 331–341.
Souza, J.C., Piccinelli, A.C., Aquino, D.F.S., Souza, V.V., Schmitz, W.O., Traesel, G.K., Cardoso, C.A.L., Kassuya, C.A.L., Arena, A.C., 2014. Toxicological analysis and antihyperalgesiC., antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barks. Nutr. Neurosci., http://dx.doi.org/10.1179/1476830514Y.0000000145.
Tewtrakul, S., Subhadhirasakul, S., Puripattanavong, J., Panphadung, T., 2003. HIV-1 protease inhibitory substances from Boesenbergia pandurate Holtt. Anim. Sci. Technol. 25, 503–508.
Tonon, R.V., Brabet, C., Hubinger, M.D., 2009. Influência da temperatura do ar de secagem e da concentracão de agente carreador sobre as propriedades físico-químicas do suco de acaí em pó. Cien. Tec. Aliment. 9, 444–450.
Tonon, R.V., Brabet, C., Hubinger, M.D., 2013. Aplicacão da secagem por atomizacão para a obtencão de produtos funcionais com alto valor agregado a partir do acaí. Inclusão Social 6, 70–71.
Velo, G.P., Dunn, C.J., Giroud, J.P., Timsit, J., Willoughby, D.A., 1973. Distribution of prostaglandins in inflammatory exudate. J. Pathol. 11, 149–158.
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DZV (PhD student): contributed to the collection and identification of plant samples, performing the laboratory work, data analysis, and drafting of the article. VSO: contributed to the development of C. adamantium microcapsules. JSA: contributed to carrying out the in vivo laboratory work. ACP: contributed to data analysis and drafted the article. CALC: Professor responsible for high-performance liquid chromatography. CALK: design and supervision of the in vivo experiments. IRM: contributed to critical reading of the manuscript. EJSA: designed the study, supervised the laboratory work, and contributed to critical reading of the manuscript. All of the authors have read the final manuscript and approved the submission.
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Viscardi, D.Z., de Oliveira, V.S., da Arrigo, J.S. et al. Anti-inflammatory, and antinociceptive effects of Campomanesia adamantium microencapsulated pulp. Rev. Bras. Farmacogn. 27, 220–227 (2017). https://doi.org/10.1016/j.bjp.2016.09.007
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DOI: https://doi.org/10.1016/j.bjp.2016.09.007