Abstract
Solanum paniculatum L., Solanaceae, locally known as “jurubeba”, is widely used in Brazil for culinary purposes, and in folk medicine to treat of diverse disorder including gastric dysfunctions. In this study we investigated the antidiarrheal activity of S. paniculatum roots extract in rats at different concentrations (125, 250 and 500mg/kg, p.o) using different experimental models such as castor oil-induced diarrhea, enteropooling and gastrointestinal motility, determined by in vivo experimental models. The major compound of root extract was characterized as chlorogenic acid based in the IR, ID and 2D NMR analysis. All the extract doses achieved antidiarrheal potency, as indicated by reduced weight of feces in castor oil-induced diarrhea, decreased intestinal motility and significantly inhibited castor oil-induced enteropooling compared to the vehicle group. The highest dose (500 mg/kg) produced greater anti-motility effect and better reduction of enteropooling, similar to the reference drug Loperamide ( 5 mg/kg). Extract from S. paniculatum L. roots had antidiarrheal activity, as shown by the lower weight of the feces as well as decrease in the accumulation of intestinal fluid and slower transit, justifying the traditional use of plant for diarrhea.
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JABT thanks CAPES for providing a scholarship. The authors are indebted to the Centro de Apoio a Pesquisa (CENAPESQ), UFRPE, for the laboratory facilities.
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JABT, DSM and TGS developed the animal model. JABT and TMGS were responsible for the collection of plant sample and the chemical studies. CSR and JABT developed the analytical methodology (HPLC). CSR and TGS designed the study and supervised the laboratory work. CSR and JABT wrote the manuscript.
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Tenório, J.A.B., do Monte, D.S., da Silva, T.M.G. et al. Solanum paniculatum root extract reduces diarrhea in rats. Rev. Bras. Farmacogn. 26, 375–378 (2016). https://doi.org/10.1016/j.bjp.2016.02.003
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DOI: https://doi.org/10.1016/j.bjp.2016.02.003