Abstract
Parkinson’s disease is a neurodegenerative disorder characterized by motor impairment, cognitive decline and psychiatric symptoms. Schinus terebinthifolius Raddi, Anacardiaceae, had been studied for its anti-inflammatory and antioxidant properties, and in this study, the stem bark was evaluated for the neuroprotective effects on behavioral and biochemical alterations induced by administrations of rotenone in rats. Behavioral evaluations were performed using open-field and rotarod. The in vitro and in vivo antioxidant activities were determined by the DPPH radical scavenging activity and lipid peroxidation method respectively. The administration of rotenone (3 mg/kg, s.c.) produced hypolocomotion, increase of immobility and muscle incoordination, while the treatment with S. terebinthifolius stem bark extract (150, 300 and 600 mg/kgp.o.) for seven days prevented rotenone-induced dysfunctional behavior. Biochemical analysis of the substantia nigra, striatum and cortex revealed that rotenone administration significantly increased lipid peroxidation, which was inhibited by treatment with all doses of S. terebinthifolius. The results suggested neuroprotective effect of S. terebinthifolius possibly mediated through its antioxidant activity, indicating a potential therapeutic benefit of this species in the treatment of Parkinson’s disease.
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The authors would like to thank CAPES for financial support. The authors also would like to dedicate this paper to Simone Sette Lopes Lafayette.
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AS, SNS, and JRS contributed in running the laboratory work, analysis of the data and drafted the paper. TJSPS and LDSA contributed in the chemicals analysis. CFBLM and JBRS contributed in the biochemical analysis. SSS, SSLL and AGW designed the study, supervised the laboratory work and contributed to the critical reading of the manuscript. All the authors have read the final manuscript and approved the submission
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Serenilo, A., Linard-Medeiros, C.F.B., Silva, S.N. et al. Schinus terebinthifolius administration prevented behavioral and biochemical alterations in a rotenone model of Parkinson’s disease. Revista Brasileira de Farmacognosia 26, 240–245 (2016). https://doi.org/10.1016/j.bjp.2015.11.005
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DOI: https://doi.org/10.1016/j.bjp.2015.11.005