Abstract
In the course of our ongoing effort to identify bioactive compounds from marine-derived fungi, the marine fungus, Penicillium species was isolated from the Red Sea tunicate, Didemnum species. Two new cerebrosides, penicillosides A and B were isolated from the marine-derived fungus, Penicillium species using different chromatographic methods. Their structures were established by different spectroscopic data including 1D (1H NMR and 13C NMR) and 2D NMR (COSY, HSQC, and HMBC) studies as well as high-resolution mass spectral data. Penicilloside A displayed antifungal activity against Candida albicans while penicilloside B illustrated antibacterial activities against Staphylococcus aureus and Escherichia coli in the agar diffusion assay. Additionally, both compounds showed weak activity against HeLa cells.
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Acknowledgement
This project was supported by the NSTIP strategic technologies program in the Kingdom of Saudi Arabia—Project No. (11-BIO1556-03). The authors also, acknowledge with thanks Science and Technology Unit, King Abdulaziz University for technical support.
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DTAY conceived and designed the experiments; analyzed the data; edited the manuscript. JMB analyzed the data; wrote the manuscript and SSAM performed the experiments, analyzed the data and wrote the manuscript.
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Murshid, S.S.A., Badr, J.M. & Yousse, D.T.A. Penicillosides A and B: new cerebrosides from the marine-derived fungus Penicillium species. Rev. Bras. Farmacogn. 26, 29–33 (2016). https://doi.org/10.1016/j.bjp.2015.09.007
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DOI: https://doi.org/10.1016/j.bjp.2015.09.007