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Synovium Derived Mesenchymal Stromal Cells (Sy-MSCs): A Promising Therapeutic Paradigm in the Management of Knee Osteoarthritis

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Abstract

Synovium-derived mesenchymal stromal cell (Sy-MSC) is a newer member of the mesenchymal stromal cell families. The first successful demonstration of the mesenchymal stromal cell from the human synovial membrane was done in 2001 and since then its potential role for musculoskeletal regeneration has been keenly documented. The regenerative effects of Sy-MSCs are through paracrine signaling, direct cell–cell interactions, and extracellular vehicles. Sy-MSCs possess superior chondrogenicity than other sources of mesenchymal stromal cells. This article aims to outline the advancement of synovium-derived mesenchymal stromal cells along with a specific insight into the application for managing osteoarthritis knee.

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Authors and Affiliations

  1. Department of Orthopaedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India

    Madhan Jeyaraman & Rajni Ranjan

  2. Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, India

    Madhan Jeyaraman, Sathish Muthu & Saurabh Kumar Jha

  3. International Association of Stemcell and Regenerative Medicine (IASRM), New Delhi, India

    Madhan Jeyaraman, Sathish Muthu, Naveen Jeyaraman, Saurabh Kumar Jha & Prabhu Mishra

  4. Department of Orthopaedics, Government Medical College & Hospital, Dindigul, Tamil Nadu, India

    Sathish Muthu

  5. Department of Orthopaedics, Kasturba Medical College, MAHE University, Manipal, Karnataka, India

    Naveen Jeyaraman

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  1. Madhan Jeyaraman
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Jeyaraman, M., Muthu, S., Jeyaraman, N. et al. Synovium Derived Mesenchymal Stromal Cells (Sy-MSCs): A Promising Therapeutic Paradigm in the Management of Knee Osteoarthritis . JOIO 56, 1–15 (2022). https://doi.org/10.1007/s43465-021-00439-w

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