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Total Sialic Acid, Antioxidant Enzyme Activities, Trace Elements, and Vitamin Status Before and After Surgery in Women with Uterine Myoma and Endometrial Cancer

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Abstract

The objective of present study was to examine endometrial tissue Be, As, Cr, Mo, Sr, Ti, Tl, Cu, Co, Se, Zn, Mn, Fe, Cd, Pb, Mg, P, erythrocytes CAT, SOD, GSH-Px, GSH, MDA, serum retinol, cholecalciferol, phylloquinone, TSA, LSA, TOS, and TAS status and to evaluate the relationships between the variables. The study had 110 participants; of these, 50 were women with uterine myoma (UM), 10 were women with endometrial cancer (EC), and 50 were healthy female subjects. In the study, vitamin analyses by HPLC and element analyses were determined using ICP-OES method. It was observed that EC group was significantly lower than healthy group in terms of levels of cholecalciferol (p < 0.05), phylloquinone (p < 0.01), GSH (p < 0.05), Fe (p < 0.05), and had a significant rise in Mg/Fe (p < 0.01) and Zn/Fe (p < 0.05) in preoperative period. UM group had significantly lower retinol (p < 0.05), phylloquinone (p < 0.001), GSH-Px (p < 0.01), GSH (p < 0.01), Cr (p < 0.01), Cu (p < 0.05), Mg (p < 0.01), and Zn (p < 0.01) levels than control group in preoperative period and significantly higher levels of MDA (p < 0.01), TSA (p < 0.01), and LSA (p < 0.01) than control group. It was found that significant associations were observed between Cu–CA 15–3 (r = 0.558, p = 0.016), Mn–CA 15–3 (r = 0.511, p = 0.030), P–CA 15–3(r =  − 0.502, p = 0.034) and with UM, also between GSH–CA-125 (r =  − 0.825, p = 0.022) and with EC group. The results of correlation analysis observed that concentrations of Cu, Mn, P, and GSH together with CA 15–3 and CA-125 levels might be important for monitoring patients with UM and EC before surgery.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Funding

This work was supported by a grant from the Van Yuzuncu Yil University (VanYYU) Scientific Research Projects Presidency (FDK/2020/6594).

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Authors and Affiliations

  1. Department of Chemistry, Division of Biochemistry, Institute of Natural and Applied Sciences, Van Yuzuncu Yil University, Van, Turkey

    Fazilet Gök, Damla Yıldız & Ahmet Bakır

  2. Department of Chemistry, Division of Biochemistry, Science Faculty, Van Yuzuncu Yil University, Van, Turkey

    Suat Ekin

  3. Department of Gynecology and Obstetrics, Division of Gynecological Oncology, Van Yuzuncu Yil University, Van, Turkey

    Erbil Karaman

  4. Department of Medical Pathology, Van Yuzuncu Yil University, Van, Turkey

    Remzi Erten

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Contributions

SE contributed to the study design and statistical analysis. FG, DY, and AB conducted the biochemical investigation and material collection. SE and EK performed data interpretation and manuscript preparation. RE contributed to the histopathology. All authors read and approved the final version of the manuscript.

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Correspondence to Suat Ekin.

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Gök, F., Ekin, S., Karaman, E. et al. Total Sialic Acid, Antioxidant Enzyme Activities, Trace Elements, and Vitamin Status Before and After Surgery in Women with Uterine Myoma and Endometrial Cancer. Reprod. Sci. 30, 2743–2757 (2023). https://doi.org/10.1007/s43032-023-01241-9

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