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KISS1 Gene Variations and Susceptibility to Idiopathic Recurrent Pregnancy Loss

  • Reproductive Genetics: Original Article
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Abstract

It is widely accepted that kisspeptin plays an integral role in the regulation of reproduction. Genetic variations in the KISS1 gene have been frequently reported to be linked to reproductive diseases, but there is still a lack of data on the association between KISS1 variations and female reproductive disorders. The present study aimed to examine the association of three missense SNPs in the KISS1 gene including rs12998, rs35431622, and rs4889 in association with idiopathic recurrent pregnancy loss (iRPL). A total of 720 individuals were recruited in this study. The DNA from the blood sample was extracted and genotyped using the PCR method. Haplotype and linkage disequilibrium (LD) have also been analyzed. The results of this study suggested that rs12998 G > A and rs4889 C > G had a significant association with iRPL (p < 0.05); while rs35431622 A > G didn’t indicate any association with iRPL. A significant association was also found for three haplotypes including C-A-A, G-G-G, and G-G-A in this population. The analysis also showed a significant LD between rs12998 and rs35431622 (P < 0.0005). The rs12998 G > A and rs4889 C > G variants of KISS1 are linked to unexplained recurrent pregnancy loss and may be risk factors for this disease.

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Acknowledgements

The author of this study would like to thank Dr. Sh. Wu and Dr. H. Xio for their assistance.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Suzhou High Tech Zone People’s Hospital, No. 95, Huashan Road, High Tech Zone, Suzhou, 215129, Jiangsu Province, China

    Fanting Meng, Aiqin Zhao, Haiying Lu, Dan Zou, Bei Dong, Xiaoqing Wang, Li Liu & Sufang Zhou

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  1. Fanting Meng
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  7. Li Liu
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Correspondence to Li Liu or Sufang Zhou.

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This study was performed in line with the principles of the Declaration of Helsinki. This research was approved by the Institutional Ethics Committee of Suzhou High-tech Zone People's Hospital with full ethical code (2020–032).

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Meng, F., Zhao, A., Lu, H. et al. KISS1 Gene Variations and Susceptibility to Idiopathic Recurrent Pregnancy Loss. Reprod. Sci. 30, 2573–2579 (2023). https://doi.org/10.1007/s43032-023-01203-1

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  • DOI: https://doi.org/10.1007/s43032-023-01203-1

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