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Improved Brain Tumor Segmentation Using UNet-LSTM Architecture

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Abstract

Brain Tumor is always known for its deadliest behavior and people’s less survival probability against it. It is a complex and life- changing medical condition where the abnormal or dead brain cell grows in and around the brain tissues. In the United States, nearly 87,000 cases are diagnosed each year increasing year by year. Brain tumor is mainly classified into two categories based on their impact on the person: Benign (non-cancerous) and Malignant (cancerous). We only focus on the cancerous tumor as it requires early detection for diagnosis. Brain Tumors are diagnosed based on the four different grades from low grade (1,2) and high grade (3,4). It is one of the hectic tasks for the medical professionals to analyze accurately. We worked on this to make the error- prone segmentation by creating the mask in the tumor region. We used MRI images as our dataset (BraTs2020) to train and segment the tumor successfully. Classes taken for segmentation are Eduma, Background, Enhancing, and Non-enhancing. Previously many methodologies have been used for segmented but we came up with integrating Long Short Term Memory (LSTM) along with U-Net architecture. U-Net is a doubled architecture of the Convolutional Neural Network model with contraction and expansive path. The accuracy, loss, and precision obtained from our work are 0.9916, 0.0240, and 0.9930 respectively.

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Data availability

The dataset used in this research is the BrsTs2020 dataset (Open source) which is called from the Kaggle web source. The link for the dataset is https://www.kaggle.com/datasets/awsaf49/brats20-dataset-training-validation

References

  1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics. CA Cancer J Clin. 2022;72(1):7–33.

    Article  Google Scholar 

  2. Çetiner H. Citrus disease detection and classification using based on convolution deep neural network. Microprocess Microsyst. 2022;95:104687. https://doi.org/10.1016/j.micpro.2022.104687.

    Article  Google Scholar 

  3. Hesamian MH, Jia W, He X, et al. Deep learning techniques for medical image segmentation: achievements and challenges. J Digit Imaging. 2019;32:582–96. https://doi.org/10.1007/s10278-019-00227-x.

    Article  Google Scholar 

  4. Al-Qazzaz S. Deep learning-based brain tumor image segmentation and its ex-tension to stroke lesion segmentation. Ph.D. dissertation, School Eng, Cardiff Univ, Cardiff, U.K; 2020. Available: https://orca.cardiff.ac.uk/id/eprint/134897/

  5. Niu K, Guo Z, Peng X, Pei S. P-ResUnet: segmentation of brain tissue with purified residual unet. Comput Biol Med. 2022. https://doi.org/10.1016/j.compbiomed.2022.106294.

    Article  Google Scholar 

  6. Mzoughi H, Njeh I, Wali A, Slima MB, BenHamida A, Mhiri C, Mahfoudhe KB. Deep multi-scale 3D convolutional neural network (CNN) for MRI gliomas brain tumor classification. J Digit Image. 2020;33(4):903–15. https://doi.org/10.1007/s10278-020-00347-9.

    Article  Google Scholar 

  7. Liu Z, Tong L, Chen L, et al. Deep learning based brain tumor segmentation: a survey. Complex Intell Syst. 2023;9:1001–26. https://doi.org/10.1007/s40747-022-00815-5.

    Article  Google Scholar 

  8. Al Nasim MA, Al Munem A, Islam M, Palash MAH, Haque MMA, Shah FM. Brain tumor segmentation using enhanced U-Net model with empirical analysis, 2022 25th International Conference on Computer and Information Technology (ICCIT), Cox’s Bazar, Bangladesh; 2022, p. 1027–32.

  9. Montaha S, Azam S, Rakibul Haque Rafid AKM, et al. Brain tumor segmentation from 3D MRI scans using U-Net. SN Comput Sci. 2023;4:386. https://doi.org/10.1007/s42979-023-01854-6.

    Article  Google Scholar 

  10. Nasim MAA, Dhali A, Afrin F, Zaman NT, Karim N. The Prominence of artificial intelligence in COVID-19. arXiv; 2021. https://doi.org/10.48550/arXiv.2111.09537

  11. Zhang C, Shen X, Cheng H, Qian Q. Brain tumor segmentation based on hybrid clustering and morphological operations. Int J Biomed Imaging. 2019;2019:1–11. https://doi.org/10.1155/2019/7305832.

    Article  Google Scholar 

  12. Walsh J, Othmani A, Jain M, Dev S. Using U-Net network for efficient brain tumor segmentation in MRI images. Healthc Anal. 2022. https://doi.org/10.1016/j.health.2022.100098.

    Article  Google Scholar 

  13. Rahman Z, Zhang R, Bhutto JA. A symmetrical approach to brain tumor segmentation in MRI using deep learning and threefold attention mechanism. Symmetry. 2023;15(10):1912. https://doi.org/10.3390/sym15101912.

    Article  Google Scholar 

  14. Anand V, Grampurohit S, Aurangabadkar P, Kori A, Khened, M, Bhat R, Krishnamurthi G. Brain tumor segmentation and survival prediction using automatic hard mining in 3D CNN architecture. 2021. In Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries: 6th International Workshop, BrainLes 2020, Held in Conjunction with MICCAI 2020, Lima, Peru, October 4, 2020, Revised Selected Papers, Part II 6 (pp. 310–319). Springer International Publishing. https://doi.org/10.1007/978-3-030-72087-2-27.

  15. Gomathi M, Dhanasekaran D. Glioma detection and segmentation using deep learning architectures. Math Stat Eng Appl. 2022;71(4):452–61. https://doi.org/10.17762/msea.v71i4.523.

    Article  Google Scholar 

  16. Singh S. A novel mask R-CNN model to segment heterogeneous brain tumors through image subtraction. ArXiv abs/2204.01201. 2022. https://doi.org/10.48550/arXiv.2204.01201

  17. Islam, M., Vibashan, V.S., Jose, V.J.M., Wijethilake, N., Utkarsh, U., Ren, H. (2020). Brain Tumor Segmentation and Survival Prediction Using 3D Attention UNet. In: Crimi, A., Bakas, S. (eds) Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries. BrainLes 2019. Lecture Notes in Computer Science, vol 11992. Springer, Cham. https://doi.org/10.1007/978-3-030-46640-4-25.

  18. Bakas, Spyridon & Reyes, Mauricio & Jakab, András & Bauer, Stefan & Rempfler, Markus & Crimi, Alessandro & Shinohara, Russell & Berger, Christoph & Ha, Sung & Rozycki, Martin & Prastawa, Marcel & Alberts, Esther & Lipkova, Jana & Freymann, John & Kirby, Justin & Bilello, Michel & Fathallah-Shaykh, Hassan & Wiest, Roland & Kirschke, Jan & Chen, Zhaolin. (2019). Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge. https://doi.org/10.48550/arXiv.1811.02629

  19. Ahmad, P., Qamar, S., Shen, L., & Saeed, A. (2021). Context aware 3D UNet for brain tumor segmentation. In Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries: 6th International Workshop, BrainLes 2020, Held in Conjunction with MICCAI 2020, Lima, Peru, October 4, 2020, Revised Selected Papers, Part I 6 (pp. 207–218). Springer International Publishing. https://doi.org/10.48550/arXiv.2010.13082

  20. Sowrirajan SR, Balasubramanian S, Raj RS. MRI Brain tumor Classification using a Hybrid VGG16-NADE model. Braz Arch Biol Technol. 2023. https://doi.org/10.1590/1678-4324-2023220071.

    Article  Google Scholar 

  21. Priyanka P, Rishabh S, Laxmi S. Image restoration of image with gaussian filter. Int Res J Eng Technol (IRJET). 2020;07(12):555–8.

    Google Scholar 

  22. Mahesh C. Comparative analysis on U-Net based Retinal Blood Vessel Segmentation. 2022 International Conference on Advances in Computing, Communication and Applied Informatics (ACCAI), Chennai, India; 2022, p. 1–5. https://doi.org/10.1109/ACCAI53970.2022.9752575.

  23. David SA, Mahesh C, Kumar VD, Polat K, Alhudhaif A, Nour M. Retinal blood vessels and optic disc segmentation using U-Net. Math Probl Eng. 2022. https://doi.org/10.1155/2022/8030954.

    Article  Google Scholar 

  24. Skourt BA, et al. Multi-scale ConvLSTM attention-based brain tumor segmentation. Int J Adv Comput Sci Appl. 2022. https://doi.org/10.14569/ijacsa.2022.0131198.

    Article  Google Scholar 

  25. Khairandish MO, Gurta R, Sharma M. A hybrid model of faster R-CNN and SVM for tumor detection and classification of MRI brain images. Int J Mech Prod Eng Res Dev. 2020;10(3):6863–6876. https://doi.org/10.13140/RG.2.2.12770.96969.

  26. Zhuge Y, Ning H, Mathen P, Cheng JY, Krauze AV, Camphausen K, Miller RW. Automated glioma grading on conventional MRI images using deep convolutional neural networks. Med Phys. 2020;47(7):3044–53 (Epub 2020 May 11 Erratum in: Med Phys. 2023 Sep;50(9):5930- 5931. PMID: 32277478; PMCID: PMC8494136.).

    Article  Google Scholar 

  27. Kamnitsas K, Ferrante E, Parisot S, Ledig C, Nori A, Criminisi A, Rueckert, Glocker B. DeepMedic for brain tumor segmentation; 2016, p. 138–49

  28. Ranjbarzadeh R, Bagherian Kasgari A, Jafarzadeh Ghoushchi S, Anari S, Naseri M, Bendechache M. Brain tumor segmentation based on deep learning and an attention mechanism using MRI multi-modalities brain images. Sci Rep. 2021;11(1):10930. https://doi.org/10.1038/s41598-021-90428-8.

    Article  Google Scholar 

  29. Shehab LH, Fahmy OM, Gasser SM, El-Mahallawy MS. An efficient brain tumor image segmentation based on deep residual networks (ResNets). J King Saud Univ Eng Sci. 2021;33(6):404–12. https://doi.org/10.1016/j.jksues.2020.06.001. (ISSN 1018-3639).

    Article  Google Scholar 

  30. Metlek S, Çetıner H. ResUNet+: a new convolutional and attention block—based approach for brain tumor segmentation. IEEE Access. 2023;11:69884–902. https://doi.org/10.1109/ACCESS.2023.3294179.

    Article  Google Scholar 

  31. Feng N, Geng X, Qin L. Study on MRI medical image segmentation technology based on CNN-CRF model. IEEE Access. 2020;8:60505–14. https://doi.org/10.1109/ACCESS.2020.2982197.

    Article  Google Scholar 

  32. Wisaeng K. U-Net++DSM: improved U-Net++ for brain tumor segmentation with deep supervision mechanism. IEEE Access. 2023. https://doi.org/10.1109/ACCESS.2023.3331025.

    Article  Google Scholar 

  33. Hu HX, Mao WJ, Lin ZZ, Hu Q, Zhang Y. Multi- modal brain tumor segmentation based on an intelligent unet-lstm algorithm in smart hospitals. ACM Trans Internet Technol. 2021. https://doi.org/10.1145/3450519.

    Article  Google Scholar 

  34. Xu F, Ma H, Sun J, Wu R, Liu X, Kong Y. LSTM Multi-modal UNet for Brain Tumor Segmentation. 2019 IEEE 4th International Conference on Image, Vision and Computing (ICIVC), Xiamen, China; 2019. p. 236–40. https://doi.org/10.1109/ICIVC47709.2019.8981027.

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Saran Raj S and Logeshwaran K S wrote the manuscript and experimented along with Anisha Devi Kalluri. All authors analyzed the results and reviewed the manuscript.

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Correspondence to Logeshwaran Karumanan Srinivasan.

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This article is part of the topical collection “Emerging Applications of Data Science for Real-World Problems” guest edited by Satyasai Jagannath Nanda, Rajendra Prasad Yadav and Mukesh Saraswat.

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Sowrirajan, S.R., Karumanan Srinivasan, L., Kalluri, A.D. et al. Improved Brain Tumor Segmentation Using UNet-LSTM Architecture. SN COMPUT. SCI. 5, 496 (2024). https://doi.org/10.1007/s42979-024-02799-0

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