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Effects of Exercise Around the Ventilation Threshold on Renal Blood Flow in Healthy Individuals

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Abstract

Purpose

High-intensity exercise reduces renal artery blood flow (RBF) compared to other forms of exercise. However, it is unclear whether moderate-intensity exercise, including those at the ventilation threshold (VT), decreases RBF. Additionally, attenuated renal autoregulation and associated blood flow can cause renal injury in patients with underlying disease. Therefore, this study aimed to confirm the changes in RBF after moderate-level exercise in healthy subjects, which will have implications for the study of renal arterial blood flow in patients with renal failure.

Methods

Cardiopulmonary exercise tests were performed by 10 healthy male participants (mean age, 31 ± 8 years): 3 min constant work-rate exercise tests, varying in exercise intensity 1 min before VT (pre-VT), after VT (post-VT), and after the respiratory compensation point (RCP). The RBF was measured using ultrasonic inspection equipment following each exercise. The VT was determined using the ventilatory equivalent method (VEQ method), while the RBF was calculated from the time-averaged flow velocity (TAV) and cross-sectional area (CSA).

Results

At baseline (resting phase), RBF was 461 ± 142 mL/min. While RBFs at pre-VT were not significantly different from those at baseline (482 ± 142 mL/min; P = 0.82), significant differences were observed at post-VT (289 ± 111 mL/min; P < 0.01 vs. baseline). RBFs at the RCP were also different from those at the baseline (212 ± 56 mL/min; P < 0.01 vs. baseline).

Conclusions

In healthy individuals, exercises varying in intensity up to the vicinity of the VT can be performed without any significant decrease in RBF.

Trial Registration Number and Registration Date

The trial was approved by an independent ethics committee at the Asahi University Hospital (approval No. 1/May/2018) and was registered (Name of the registry: Changes of renal blood flow with exercise load. Consideration using ultrasonic inspection equipment. UMIN000035598, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000040561, 24/January/2019).

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Data Availability Statement

Upon a reasonable request, derived data supporting the findings of this study are available from the corresponding author.

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Acknowledgements

The authors thank all members of the Department of Cardiology, Asahi University Hospital, and Shinichi Arizono.

Funding

The authors declare that no support, financial or otherwise, was received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Rehabilitation, Asahi University Hospital, 3-23 Hashimoto, Gifu, Gifu, Japan

    Yoshitatsu Fukuta & Junichi Magata

  2. School of Health Sciences, Seirei Christopher University, Mikatahara, Hamamatsu, Shizuoka, Japan

    Yoshitatsu Fukuta, Shinichi Arizono & Yuuichi Tawara

  3. Department of Cardiology, Asahi University Hospital, 3-23 Hashimoto, Gifu, Gifu, Japan

    Shinichiro Tanaka, Tomonori Kawaguchi, Natsumi Tsugita, Takahiro Fuseya & Tomonori Segawa

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Contributions

YF contributed to literature research, study design, data analysis, manuscript preparation, and manuscript review. SA contributed to study design, data analysis, and manuscript preparation. ST contributed to study design and data collection. TK, NT, TF, and JM contributed to data collection. YT contributed to data collection and study design. TS contributed to data collection. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yoshitatsu Fukuta.

Ethics declarations

Conflict of Interest

Shinichi Arizono reports grants from Hoshi Iryo-Sanki Co. Ltd and NPO Central Japan Lung Study Group outside the submitted work. All other authors declare that they have no competing interests.

Ethics Approval and Consent to Participate

This trial was approved by an independent ethics committee at the Asahi University Hospital (Approval No. 1/May/2018) and was registered (Name of the registry: Changes of renal blood flow with exercise load. Consideration using ultrasonic inspection equipment.UMIN 000035598, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000040561, 24/January/2019). All test subjects were volunteers who were informed about the details of the study. Written consent to participate was obtained from all the participants before enrollment in the study.

Consent for Publication

Not applicable.

Consent to Participate

Informed consent was obtained from all individual participants included in the study.

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Fukuta, Y., Arizono, S., Tanaka, S. et al. Effects of Exercise Around the Ventilation Threshold on Renal Blood Flow in Healthy Individuals. J. of SCI. IN SPORT AND EXERCISE 6, 44–51 (2024). https://doi.org/10.1007/s42978-022-00216-7

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  • DOI: https://doi.org/10.1007/s42978-022-00216-7

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