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Medicinal plants, phytoconstituents and traditional formulation as potential therapies for SARS-CoV-2: a review update

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Abstract

The novel coronavirus known as SARS-CoV-2 is the causative agent of the COVID-19 pandemic resulting in more than 6.9 million deaths worldwide. Currently, the therapeutic strategies only recommend various available vaccines as the preventive measure against COVID-19 with no established effective preventive or therapeutic drugs so far reported. The various herbal derivatives, and their secondary metabolites were reported with varying range of efficacy. Accordingly this review of literature has discussed in detail the insight of the plant derived formulations against SARS-CoV-2. This in-silico analysis has encompassed the extensive doctrine data base search of google scholar, pubmed, science direct and scopus with specific search using keywords “inhibitory role of medicinal plants/ bioactive metabolites/ traditional herbal medicine/ plant products/ secondary metabolites/ phytoconstituents against SARS-CoV-2/COVID-19”. Among the yielded search of 1539 literature, 107 were found relevant and analysed in the present review. Various medicinal plants and their natural products were studied and reported for their inhibitory activity against SARS-CoV-2 after their rigorous testing in various clinical trials. Promising result were reported in Ashwagandha (Withania somnifera), Giloy (Tinospora cordifolia), Neem (Azadirachta indica) Pipli (Piper longum), Haldi (Curcuma longa) and Tulsi (Ocimum sanctum) and phytoconstituents like curcumin, colchicine, chloroquine, shikimic acid, quercetin, nimbolin, tinosponone, withanoside, piperolactam verimol, vicenin and myricetin. Various concoctions from these medicinal plants and their phytoconstituents have been reported of virucidal/ virustatic properties against SARS-CoV-2 along with immunomodulatory, anti-inflammatory, anti-oxidant and antipyretic effect.

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  1. Department of Microbiology, All India Institute of Medical Sciences, 492099, Raipur, Chhattisgarh, India

    Pushpendra Singh, Kuldeep Sharma, Anudita Bhargava & Sanjay Singh Negi

  2. Department of Biophysics, All India Institute of Medical Sciences, 110029, New Delhi, India

    Manish Kumar Tripathi

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Singh, P., Tripathi, M.K., Sharma, K. et al. Medicinal plants, phytoconstituents and traditional formulation as potential therapies for SARS-CoV-2: a review update. Vegetos (2023). https://doi.org/10.1007/s42535-023-00706-1

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