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Intraosseous Neurofibroma in the Mandible: Two Rare Case Reports

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Abstract

Neurofibroma is the most common type of peripheral nerve neoplasm arising from a mixture of cell types, including Schwann cells and perineurial fibroblasts. We report two unusual cases where patients presented with intraosseous swelling of the jaw. On clinical examination, both patients presented with swelling of the jaw. Imaging showed ill-defined radiolucency in one case and well-defined corticated radiolucency with a soap-bubble appearance in the other case. Biopsy with adjuvant immunohistochemistry revealed features suggestive of neurofibroma. Both cases were managed surgically. The second case in the male patient was recurrent and transformed into atypical neurofibroma. Despite being a benign tumor, neurofibroma is locally aggressive. Commonly found in soft tissues of the body, neurofibromas are rare in the head and neck region. But the intraosseous location of this tumor in the mandible is an exceptional case.

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Acknowledgements

The authors wish to thank all postgraduate students of GDCH Nagpur.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital, CSMT-400001, Mumbai, Maharashtra, India

    Riya Jain

  2. Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital, Nagpur, Maharashtra, India

    Suchitra Gosavi

  3. Department of Oral and Maxillofacial Surgery, Government Dental College and Hospital, Nagpur, Maharashtra, India

    Abhay Datarkar

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  1. Riya Jain
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  2. Suchitra Gosavi
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  3. Abhay Datarkar
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Dr. Riya Jain, Dr. Suchitra Gosavi, and Dr. Abhay Datarkar formulated the manuscript and data collection.

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Correspondence to Riya Jain.

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Jain, R., Gosavi, S. & Datarkar, A. Intraosseous Neurofibroma in the Mandible: Two Rare Case Reports. SN Compr. Clin. Med. 5, 102 (2023). https://doi.org/10.1007/s42399-023-01441-z

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