Abstract
Inherited Factor VII deficiency is an autosomal recessive coagulation disorder with broad range of bleeding manifestations. The association between bleeding and absolute Factor VII level is poor. Usually, the bleeding is associated with FVII levels of less than 1% of the normal value. Factor VII deficiency is associated with prolongation of prothrombin time only with normal activated partial thromboplastin time. Very few pregnant women have been reported with Factor VII deficiency so far in English literature. We, hereby, report 2 cases along with the review of literature of Factor VII deficiency during pregnancy. Our patients were diagnosed to have Factor VII deficiency after deranged coagulogram with Factor VII level of < 1% and 17.1%, respectively, however could be managed by fresh frozen plasma only in first case and fresh frozen plasma and Factor VII concentrate in second case successfully. Coagulation profile is a simple, easily available, affordable, and life-saving investigation to detect this deficiency in pregnancy. Decision regarding replacement therapy should be individualized on a case-to-case basis.
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Minakshi Rohilla—(1) substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; (2) drafted and revised the article critically for important intellectual content; and (3) final approval of the version to be published.
Rakhi Rai—(1) substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; (2) drafted and revised the article critically for important intellectual content; and (3) final approval of the version to be published.
Jasmina Ahluwalia—(1) substantial contributions to conception and design, analysis, and interpretation of data; (2) revised the article critically for important intellectual content; and (3) final approval of the version to be published.
Pankaj Malhotra—(1) substantial contributions to conception and design, analysis, and interpretation of data; (2) revised the article critically for important intellectual content; and (3) final approval of the version to be published.
Vanita Jain—(1) substantial contributions to conception and design, analysis, and interpretation of data; (2) revised the article critically for important intellectual content; and (3) final approval of the version to be published.
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Patient Perspective
We were satisfied with the management. We were not aware of the FVII deficiency. The diagnosis will help us in planning future pregnancies. We will be more careful in our day-to-day activities to prevent any injury.
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Rohilla, M., Rai, R., Ahluwalia, J. et al. Factor VII Deficiency and Pregnancy: Case Report and Review of Literature. SN Compr. Clin. Med. 3, 2650–2654 (2021). https://doi.org/10.1007/s42399-021-01037-5
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DOI: https://doi.org/10.1007/s42399-021-01037-5