Abstract
Chondroma is a rare benign tumor of the brain and may present initially with seizure or other mass-occupying manifestations. A 26-year-old man with generalized tonic-clonic seizure was admitted to the emergency department. The duration of the seizure was 5 minutes, and the seizure ceased with intravenous diazepam and phenytoin. In magnetic resonance imaging (MRI), there was a hypo-intense mass-like parafalcine lesion in T1 and hyper-intense in T2 with lobulation and no significant brain edema. On the fourth postoperative day, there was CSF leakage from the skin. The patient underwent another operation for CSF leakage. The patient was discharged after 1 week with Glasgow Coma Scale (GCS) 15/15, and no neurological deficits. In the follow-up examinations, the seizure was eliminated. Follow-up CT scan showed significant remodeling of the brain. Concise perioperative planning and meticulous surgical approach are required for parafalcine chondroma. Long-term survival is favorable.
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References
Linsen M, Junmei W, Liwei Z, Jianping D, Xuzhu C. An intracranial chondroma with intratumoral and subarachnoidal hemorrhage. Neurol India. 2011;59(2):310–3.
Erdogan S, Zorludemir S, Erman T, Akgul E, Ergin M, Ildan F, et al. Chondromas of the falx cerebri and dural convexity: report of two cases and review of the literature. J Neuro-Oncol. 2006;80(1):21–5.
Fountas KN, Stamatiou S, Barbanis S, Kourtopoulos H. Intracranial falx chondroma: literature review and a case report. Clin Neurol Neurosurg. 2008;110(1):8–13.
Agrawal R, Saroha A. Intracranial chondroma of the falx cerebri: a rare case report with review of literature. Asian J Neurosurg. 2019;14(3):911–4.
Abeloos L, Maris C, Salmon I, Balériaux D, Sadeghi N, Lefranc F. Chondroma of the dural convexity: a case report and literature review. Neuropathology. 2012;32(3):306–10.
Çolpan E, Attar A, Erekul S, Arasıl E. Convexity dural chondroma: a case report and review of the literature. J Clin Neurosci. 2003;10(1):106–8.
Sullivan JC, Goldsmith J, Rojas R, Varma H, Kasper EM. Intracranial dural parafalcine chondroma: case report and systematic review of the literature. World Neurosurg. 2019;122:1–7.
Nikoobakht M, Shojaei H, Baseri YK, Shojaei SF. An intraventricular type of chondroma: a case report. Turkish Neurosurg. 2020;30(2):303–6.
Fuji H, Nakasu Y, Ishida Y, Horiguchi S, Mitsuya K, Kashiwagi H, et al. Feasibility of proton beam therapy for chordoma and chondrosarcoma of the skull base. Skull Base. 2011;21(3):201–6.
Roth P, Regli L, Tonder M, Weller M. Tumor-associated edema in brain cancer patients: pathogenesis and management. Expert Rev Anticancer Ther. 2013;13(11):1319–25.
Delgado-López P, Martín-Velasco V, Galacho-Harriero AM, Castilla-Díez J, Rodríguez-Salazar A, Echevarría-Iturbe C. Large chondroma of the dural convexity in a patient with Noonan's syndrome. Case report and review of the literature. Neurocirugía. 2007;18(3):241–6.
Higashida T, Sakata K, Kanno H, Tanabe Y, Kawasaki T, Yamamoto I. Intracranial chondroma arising from the skull base: two case reports featuring the image findings for differential diagnosis. No Shinkei Geka Neurol Surg. 2007;35(5):495–501.
Park J-H, Jeun S-S. An intracranial chondroma with intratumoral hemorrhage: a case report and review of the literature. Brain Tumor Res Treat. 2013;1(1):42–4.
Geng S, Zhang J, Zhang LW, Wu Z, Jia G, Xiao X, et al. Diagnosis and microsurgical treatment of chondromas and chondrosarcomas of the cranial base. Oncol Lett. 2014;8(1):301–4.
Ramina R, Neto MC, Meneses MS, Pedrozo AA. Maffucci’s syndrome associated with a cranial base chondrosarcoma: case report and literature review. Neurosurgery. 1997;41(1):269–72.
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AS contributed to the conception of the work, data search, data gathering, patient treatment, manuscript preparation, manuscript revision, final approval of the manuscript, and agreed to be accountable for all aspects of the work.
HM contributed to the conception of the work, data search, patient treatment, manuscript preparation, manuscript revision, final approval of the manuscript and agreed to be accountable for all aspects of the work.
MS contributed to patient treatment, manuscript revision, final approval of the manuscript, and agreed to be accountable for all aspects of the work.
BA contributed to patient treatment, manuscript revision, final approval of the manuscript, and agreed to be accountable for all aspects of the work.
SBM contributed to the data search, manuscript preparation, manuscript revision, final approval of the manuscript, and agreed to be accountable for all aspects of the work.
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Moin, H., Sourani, A., Sabouri, M. et al. Large Parafalcine Chondroma Presenting with Seizure: A Case Report. SN Compr. Clin. Med. 3, 1973–1977 (2021). https://doi.org/10.1007/s42399-021-00946-9
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DOI: https://doi.org/10.1007/s42399-021-00946-9