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Hypoparathyroidism: is it that easy to treat?

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Abstract

Hypoparathyroidism is a relatively rare endocrine disease characterised by either null or inappropriately low secretion of parathyroid hormone (PTH) for serum calcium levels. The other main laboratory findings include hypocalcaemia, inappropriately normal or high urine calcium excretion and hyperphosphataemia with low urine phosphate excretion. The management of hypoparathyroidism should be tailored to each individual case, which makes it a demanding undertaking in everyday clinical practice. In this review, we sought to focus on the diagnostic approach of hypoparathyroidism and the therapeutic challenges of the disease from a clinical perspective. Conventional treatment with vitamin D analogues and calcium salts is no longer the only available treatment, since replacement treatment with PTH(1-84) has recently been approved for the disease. However, the optimal treatment schedule is yet to be defined.

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Article 31 August 2017

Michael Mannstadt, John P. Bilezikian, … Dolores M. Shoback

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, 1st Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Evangelia Triantafyllou & Maria P. Yavropoulou

  2. Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece

    Athanasios D. Anastasilakis

  3. Department of Endocrinology and Diabetes, 251 Hellenic Air Force & VA General Hospital, 3 Kanellopoulou St, 11525, Athens, Greece

    Polyzois Makras

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  1. Evangelia Triantafyllou
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  2. Maria P. Yavropoulou
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  3. Athanasios D. Anastasilakis
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  4. Polyzois Makras
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Correspondence to Polyzois Makras.

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This article is a product of the 5th ENDO COMBO, during which a lecture under the same title was presented as part of the course by the senior author.

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Triantafyllou, E., Yavropoulou, M.P., Anastasilakis, A.D. et al. Hypoparathyroidism: is it that easy to treat?. Hormones 18, 55–63 (2019). https://doi.org/10.1007/s42000-018-0032-6

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