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Bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints

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Key summary points

AbstractSection Aim

This study examined the bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints (SMCs).

AbstractSection Findings

An independent effect of baseline physical performance on the change of depressive symptoms over time and an independent effect of baseline depressive symptoms on the change of physical performance over time were found.

AbstractSection Message

Since depressive symptoms and physical performance had a bidirectional relationship, improvement of one may improve the other.

Abstract

Purpose

This study examined the bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints.

Methods

Secondary analyses using data from the Multidomain Alzheimer Preventive Trial (MAPT) study were performed. The participants were 1679 subjects (female, 64.8%; mean age, 75.3 ± 4.4 years). The outcome measures were depressive symptoms assessed by the 15-item Geriatric Depression Scale (GDS) and physical performance assessed by the Short Physical Performance Battery (SPPB) and handgrip strength (HGS). All measurements were performed at baseline and at 6, 12, 24, and 36 months. The bidirectional relationships of GDS with SPPB and HGS were examined using mixed-effect regression analysis.

Results

Baseline physical performance was significantly associated with a decreased GDS score (SPPB score: β = − 0.210, 95% confidence interval [CI], − 0.283 to − 0.137; HGS: β = − 0.038, 95% CI − 0.056 to − 0.019). The baseline GDS score was significantly associated with decreased physical performance (SPPB score: β = − 0.082, 95% CI − 0.107 to − 0.056; HGS: β = − 0.261, 95% CI − 0.370 to − 0.152).

Conclusion

Since depressive symptoms and physical performance had a bidirectional relationship, prevention or improvement of decreased physical performance could play a role in reducing depressive symptoms, and addressing depressive symptoms may play a role in improving physical performance.

Trial registration number

NCT01513252.

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Acknowledgements

The MAPT study was supported by grants from the Gérontopôle of Toulouse, the French Ministry of Health (PHRC 2008, 2009), Pierre Fabre Research Institute (manufacturer of the omega-3 supplement), Exhonit Therapeutics SA, and Avid Radiopharmaceuticals Inc. The promotion of this study was supported by the University Hospital Center of Toulouse. The data-sharing activity was supported by the Association Monegasque pour la Recherche sur la maladie d’Alzheimer (AMPA) and the UMR 1027 Unit INSERM-University of Toulouse III.

MAPT Study Group: Principal investigator: Bruno Vellas (Toulouse); Coordination: Sophie Guyonnet; Project leader: Isabelle Carrié; CRA: Lauréane Brigitte; Investigators: Catherine Faisant, Françoise Lala, Julien Delrieu, Hélène Villars; Psychologists: Emeline Combrouze, Carole Badufle, Audrey Zueras; Methodology, statistical analysis and data management: Sandrine Andrieu, Christelle Cantet, Christophe Morin; Multidomain group: Gabor Abellan Van Kan, Charlotte Dupuy, Yves Rolland (physical and nutritional components), Céline Caillaud, Pierre-Jean Ousset (cognitive component), Françoise Lala (preventive consultation), Bertrand Fougère (Toulouse). The cognitive component was designed in collaboration with Sherry Willis from the University of Seattle, and Sylvie Belleville, Brigitte Gilbert, and Francine Fontaine from the University of Montreal. Co-Investigators in associated centers: Jean-François Dartigues, Isabelle Marcet, Fleur Delva, Alexandra Foubert, Sandrine Cerda (Bordeaux); Marie-Noëlle-Cuffi, Corinne Costes (Castres); Olivier Rouaud, Patrick Manckoundia, Valérie Quipourt, Sophie Marilier, Evelyne Franon (Dijon); Lawrence Bories, Marie-Laure Pader, Marie-France Basset, Bruno Lapoujade, Valérie Faure, Michael Li Yung Tong, Christine Malick-Loiseau, Evelyne Cazaban-Campistron (Foix); Françoise Desclaux, Colette Blatge (Lavaur); Thierry Dantoine, Cécile Laubarie-Mouret, Isabelle Saulnier, Jean-Pierre Clément, Marie-Agnès Picat, Laurence Bernard-Bourzeix, Stéphanie Willebois, Iléana Désormais, Noëlle Cardinaud (Limoges); Marc Bonnefoy, Pierre Livet, Pascale Rebaudet, Claire Gédéon, Catherine Burdet, Flavien Terracol (Lyon), Alain Pesce, Stéphanie Roth, Sylvie Chaillou, Sandrine Louchart (Monaco); Kristelle Sudres, Nicolas Lebrun, Nadège Barro-Belaygues (Montauban); Jacques Touchon, Karim Bennys, Audrey Gabelle, Aurélia Romano, Lynda Touati, Cécilia Marelli, Cécile Pays (Montpellier); Philippe Robert, Franck Le Duff, Claire Gervais, Sébastien Gonfrier (Nice); Yannick Gasnier and Serge Bordes, Danièle Begorre, Christian Carpuat, Khaled Khales, Jean-François Lefebvre, Samira Misbah El Idrissi, Pierre Skolil, Jean-Pierre Salles (Tarbes). MRI group: Carole Dufouil (Bordeaux), Stéphane Lehéricy, Marie Chupin, Jean-François Mangin, Ali Bouhayia (Paris); Michèle Allard (Bordeaux); Frédéric Ricolfi (Dijon); Dominique Dubois (Foix); Marie Paule Bonceour Martel (Limoges); François Cotton (Lyon); Alain Bonafé (Montpellier); Stéphane Chanalet (Nice); Françoise Hugon (Tarbes); Fabrice Bonneville, Christophe Cognard, François Chollet (Toulouse). PET scans group: Pierre Payoux, Thierry Voisin, Julien Delrieu, Sophie Peiffer, Anne Hitzel, (Toulouse); Michèle Allard (Bordeaux); Michel Zanca (Montpellier); Jacques Monteil (Limoges); Jacques Darcourt (Nice). Medico-economics group: Laurent Molinier, Hélène Derumeaux, Nadège Costa (Toulouse). Biological sample collection: Christian Vincent, Bertrand Perret, Claire Vinel (Toulouse). Safety management: Pascale Olivier-Abbal. DSA Group: Sandrine Andrieu, Christelle Cantet, Nicola Coley

Funding

The MAPT study was supported by grants from the Gérontopôle of Toulouse, the French Ministry of Health (PHRC 2008, 2009), Pierre Fabre Research Institute (manufacturer of the omega-3 supplement), Exhonit Therapeutics SA, and Avid Radiopharmaceuticals, Inc. The promotion of this study was supported by the University Hospital Center of Toulouse. The data sharing activity was supported by the Association Monegasque pour la Recherche sur la maladie d’Alzheimer (AMPA) and the UMR 1027 Unit INSERM-University of Toulouse III.

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Authors and Affiliations

  1. Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Toulouse, France

    Eiko Takano, Mathieu Maltais & Yves Rolland

  2. Center of Assistive Robotics and Rehabilitation for Longevity and Good Health, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, 474-8511, Japan

    Eiko Takano & Izumi Kondo

  3. Faculté de Médecine Et Sciences de La Santé Centre de Recherche Sur Le Vieillissement, Sherbrooke, QC, Canada

    Mathieu Maltais

  4. Faculté Des Sciences de L’Activité Physique, Université de Sherbrooke, Sherbrooke, QC, Canada

    Mathieu Maltais

  5. UMR INSERM 1027, University of Toulouse III, Toulouse, France

    Yves Rolland

Authors
  1. Eiko Takano
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  2. Mathieu Maltais
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  3. Izumi Kondo
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  4. Yves Rolland
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Consortia

for the MAPT/DSA group

  • Bruno Vellas
  • , Sophie Guyonnet
  • , Isabelle Carrié
  • , Lauréane Brigitte
  • , Catherine Faisant
  • , Françoise Lala
  • , Julien Delrieu
  • , Hélène Villars
  • , Emeline Combrouze
  • , Carole Badufle
  • , Audrey Zueras
  • , Sandrine Andrieu
  • , Christelle Cantet
  • , Christophe Morin
  • , Gabor Abellan Van Kan
  • , Charlotte Dupuy
  • , Yves Rolland
  • , Céline Caillaud
  • , Pierre-Jean Ousset
  • , Françoise Lala
  • , Bertrand Fougère
  • , Sherry Willis
  • , Sylvie Belleville
  • , Brigitte Gilbert
  • , Francine Fontaine
  • , Jean-François Dartigues
  • , Isabelle Marcet
  • , Fleur Delva
  • , Alexandra Foubert
  • , Sandrine Cerda
  • ,  Marie-Noëlle-Cuffi
  • , Corinne Costes
  • , Olivier Rouaud
  • , Patrick Manckoundia
  • , Valérie Quipourt
  • , Sophie Marilier
  • , Evelyne Franon
  • , Lawrence Bories
  • , Marie-Laure Pader
  • , Marie-France Basset
  • , Bruno Lapoujade
  • , Valérie Faure
  • , Michael Li Yung Tong
  • , Christine Malick-Loiseau
  • , Evelyne Cazaban-Campistron
  • , Françoise Desclaux
  • , Colette Blatge
  • , Thierry Dantoine
  • , Cécile Laubarie-Mouret
  • , Isabelle Saulnier
  • , Jean-Pierre Clément
  • , Marie-Agnès Picat
  • , Laurence Bernard-Bourzeix
  • , Stéphanie Willebois
  • , Iléana Désormais
  • , Noëlle Cardinaud
  • , Marc Bonnefoy
  • , Pierre Livet
  • , Pascale Rebaudet
  • , Claire Gédéon
  • , Catherine Burdet
  • , Flavien Terracol
  • , Alain Pesce
  • , Stéphanie Roth
  • , Sylvie Chaillou
  • , Sandrine Louchart
  • , Kristelle Sudres
  • , Nicolas Lebrun
  • , Nadège Barro-Belaygues
  • , Jacques Touchon
  • , Karim Bennys
  • , Audrey Gabelle
  • , Aurélia Romano
  • , Lynda Touati
  • , Cécilia Marelli
  • , Cécile Pays
  • , Philippe Robert
  • , Franck Duff
  • , Claire Gervais
  • , Sébastien Gonfrier
  • , Yannick Gasnier
  • , Serge Bordes
  • , Danièle Begorre
  • , Christian Carpuat
  • , Khaled Khales
  • , Jean-François Lefebvre
  • , Samira Misbah El Idrissi
  • , Pierre Skolil
  • , Jean-Pierre Salles
  • , Carole Dufouil
  • , Stéphane Lehéricy
  • , Marie Chupin
  • , Jean-François Mangin
  • , Ali Bouhayia
  • , Michèle Allard
  • , Frédéric Ricolfi
  • , Dominique Dubois
  • , Marie Paule Bonceour Martel
  • , François Cotton
  • , Alain Bonafé
  • , Stéphane Chanalet
  • , Françoise Hugon
  • , Fabrice Bonneville
  • , Christophe Cognard
  • , François Chollet
  • , Pierre Payoux
  • , Thierry Voisin
  • , Julien Delrieu
  • , Sophie Peiffer
  • , Anne Hitzel
  • , Michèle Allard
  • , Michel Zanca
  • , Jacques Monteil
  • , Jacques Darcourt
  • , Laurent Molinier
  • , Hélène Derumeaux
  • , Nadège Costa
  • , Christian Vincent
  • , Bertrand Perret
  • , Claire Vinel
  • , Pascale Olivier-Abbal
  • , Sandrine Andrieu
  • , Christelle Cantet
  •  & Nicola Coley

Contributions

ET contributed to study concept, interpretation of data, statistical analyses, and drafting the article. MM contributed to study concept and design, statistical advice, and critical revision of the article for important intellectual content. IK and YR contributed to critical revision of the article for important intellectual content.

Corresponding author

Correspondence to Eiko Takano.

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Conflict of interest

The authors report no conflicts of interest.

Ethics approval

The ethics committee in Toulouse (Comité de Protections des Personnes, Sud-Ouest et Outre-Mer II, CPP SOOM II) approved the study.

Informed consent

Written, informed consent was obtained from all participants.

Consent for publication

The participants consented to publication.

Availability of data and material

The data that support the findings of this study are available from the corresponding author upon reasonable request. The protocol is registered in a public-access clinical trial database (www.clinicaltrials.gov, Number: NCT01513252).

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The list of MAPT/DSA group members were listed in Acknowledgements section.

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Takano, E., Maltais, M., Kondo, I. et al. Bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints. Eur Geriatr Med 12, 973–980 (2021). https://doi.org/10.1007/s41999-021-00473-9

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