Key summary points
This review article describes medication reconciliation and medication review processes, their effectiveness among older people, and the implementation issues in daily practice.
AbstractSection FindingsMedication reconciliation and medication review are two distinct but complementary clinical processes that may be efficient to decrease drug-related problems and prevent adverse drug events. Effectiveness and successful implementation of medication reconciliation and medication review require cautious acknowledgement of human factors and organizational issues and alignment of treatment recommendations with patient preferences and goals
AbstractSection MessageThe involvement of geriatricians remains essential for the successful implementation of medication reconciliation and medication review in geriatric settings and thus better drug risk management for older patients.
Abstract
Older people are frequently exposed to polypharmacy, inappropriate prescribing, and adverse drug events. Two clinical processes can help geriatricians to optimize and increase the safety of drug prescriptions for older adults: medication reconciliation and medication review. Medication reconciliation provides the best possible medication history and identifies and resolves discrepancies in drug prescriptions. During the medication review, the best possible medication history is crosschecked against other data, including morbidities, patient’s preferences, or geriatric syndromes, to produce a personalized medication strategy. Alignment of treatment recommendations with patient preferences and goals through shared decision-making is particularly important in medication review. Medication reconciliation and medication review have proven to be effective, but their broad implementation remains difficult. Indeed, these procedures are time-consuming and require specific skills, coordination between different healthcare professionals, organizations and dedicated means. The involvement of geriatricians therefore remains essential for the successful implementation of medication reconciliation and medication review in geriatric settings and among frail older people.
Similar content being viewed by others
References
Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B (2012) Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 380:37–43
Payne RA, Avery AJ, Duerden M, Saunders CL, Simpson CR, Abel GA (2014) Prevalence of polypharmacy in a Scottish primary care population. Eur J Clin Pharmacol 70:575–581
Kwan JL, Lo L, Sampson M, Shojania KG (2013) Medication reconciliation during transitions of care as a patient safety strategy: a systematic review. Ann Intern Med 158(5 Pt 2):397–403
Mekonnen AB, McLachlan AJ, Brien JAE (2016) Pharmacy-led medication reconciliation programmes at hospital transitions: a systematic review and meta-analysis. J Clin Pharm Ther. 41:128–144
Lehnbom EC, Stewart MJ, Manias E, Westbrook JI (2014) Impact of medication reconciliation and review on clinical outcomes. Ann Pharmacother 48:1298–1312
Geurts MME, Talsma J, Brouwers JRBJ, de Gier JJ (2012) Medication review and reconciliation with cooperation between pharmacist and general practitioner and the benefit for the patient: a systematic review. Br J Clin Pharmacol 74:16–33
Christensen M, Lundh A (2016) Medication review in hospitalised patients to reduce morbidity and mortality. Cochrane Database Syst Rev 2:8986
Medication Reconciliation Review | IHI - Institute for Healthcare Improvement. http://www.ihi.org:80/resources/Pages/Tools/MedicationReconciliationReview.aspx. Accessed 2 Oct 2020.
Nassaralla CL, Naessens JM, Hunt VL, Bhagra A, Chaudhry R, Hansen MA et al (2009) Medication reconciliation in ambulatory care: attempts at improvement. Qual Saf Health Care 18:402–407
Murphy EM, Oxencis CJ, Klauck JA, Meyer DA, Zimmerman JM (2009) Medication reconciliation at an academic medical center: implementation of a comprehensive program from admission to discharge. Am J Health-Syst Pharm AJHP Off J Am Soc Health-Syst Pharm 66:2126–2131
Redmond P, Grimes TC, McDonnell R, Boland F, Hughes C, Fahey T (2018) Impact of medication reconciliation for improving transitions of care. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD010791.pub2
MacKinnon NJ (2006) Commentary: Medication reconciliation—a new opportunity for geriatric medicine. Can J Geriatr 9:109
Leotsakos A, Zheng H, Croteau R, Loeb JM, Sherman H, Hoffman C et al (2014) Standardization in patient safety: the WHO High 5s project. Int J Qual Health Care 26:109–116
Buck TC, Gronkjaer LS, Duckert M-L, Rosholm J-U, Aagaard L (2013) Medication reconciliation and prescribing reviews by pharmacy technicians in a geriatric ward. J Res Pharm Pract 2:145–150
Mixon AS, Smith GR, Mallouk M, Nieva HR, Kripalani S, Rennke S et al (2019) Design of MARQUIS2: study protocol for a mentored implementation study of an evidence-based toolkit to improve patient safety through medication reconciliation. BMC Health Serv Res 19:659
Stolldorf DP, Schnipper JL, Mixon AS, Dietrich M, Kripalani S (2019) Organisational context of hospitals that participated in a multi-site mentored medication reconciliation quality improvement project (MARQUIS2): a cross-sectional observational study. BMJ Open 9:e030834
Rankin A, Cadogan CA, Patterson SM, Kerse N, Cardwell CR, Bradley MC et al (2018) Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev 9:8165
Mangin D, Bahat G, Golomb BA, Mallery LH, Moorhouse P, Onder G et al (2018) International group for reducing inappropriate medication use & polypharmacy (IGRIMUP): position statement and 10 recommendations for action. Drugs Aging 35:575–587
Donaldson LJ, Kelley ET, Dhingra-Kumar N, Kieny M-P, Sheikh A (2017) Medication without harm: WHO’s third global patient safety challenge. Lancet Lond Engl 389:1680–1681
National Institute for Health and Care Excellence. Medicines optimisation: the safe and effective use of medicines to enable the best possible outcomes. https://www.nice.org.uk/guidance/ng5. Accessed 2 Oct 2020.
Blenkinsopp A, Bond C, Raynor DK (2012) Medication reviews. Br J Clin Pharmacol 74:573–580
Alhawassi TM, Krass I, Bajorek BV, Pont LG (2014) A systematic review of the prevalence and risk factors for adverse drug reactions in the elderly in the acute care setting. Clin Interv Aging 9:2079–2086
Budnitz DS, Lovegrove MC, Shehab N, Richards CL (2011) Emergency hospitalizations for adverse drug events in older Americans. N Engl J Med 365:2002–2012
Jansen J, Naganathan V, Carter SM, McLachlan AJ, Nickel B, Irwig L et al (2016) Too much medicine in older people? Deprescribing through shared decision making. BMJ 353:i2893
Spinewine A, Schmader KE, Barber N, Hughes C, Lapane KL, Swine C et al (2007) Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet Lond Engl 370:173–184
Gallagher P, Ryan C, Byrne S, Kennedy J, Omahony D (2008) STOPP (screening tool of older person’s prescriptions) and START (screening tool to alert doctors to right treatment). Consensus validation. Int J Clin Pharmacol Ther 46:72–83
Omahony D, Osullivan D, Byrne S, Oconnor MN, Ryan C, Gallagher P (2014) STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing 2:145
O’Mahony D (2020) STOPP/START criteria for potentially inappropriate medications/potential prescribing omissions in older people: origin and progress. Expert Rev Clin Pharmacol 13:15–22
American Geriatrics Society (2019) Updated AGS beers criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2019(67):674–694
Rognstad S, Brekke M, Fetveit A, Spigset O, Wyller TB, Straand J (2009) The Norwegian General Practice (NORGEP) criteria for assessing potentially inappropriate prescriptions to elderly patients. A modified Delphi study. Scand J Prim Health Care 27:153–159
Laroche M-L, Charmes J-P, Merle L (2007) Potentially inappropriate medications in the elderly: a French consensus panel list. Eur J Clin Pharmacol 63:725–731
Holt S, Schmiedl S, Thürmann PA (2010) Potentially inappropriate medications in the elderly: the PRISCUS list. Dtsch Arzteblatt Int 107:543–551
Kuhn-Thiel AM, Weiß C, Wehling M (2014) The FORTA authors/expert panel members. Consensus Validation of the FORTA (Fit fOR The Aged) list: a clinical tool for increasing the appropriateness of pharmacotherapy in the elderly. Drugs Aging. 31:131–140
Hanlon JT, Schmader KE, Samsa GP, Weinberger M, Uttech KM, Lewis IK et al (1992) A method for assessing drug therapy appropriateness. J Clin Epidemiol 45:1045–1051
Anrys P, Boland B, Degryse J-M, De Lepeleire J, Petrovic M, Marien S et al (2016) STOPP/START version 2-development of software applications: easier said than done? Age Ageing 45:589–592
Dalton K, O’Brien G, O’Mahony D, Byrne S (2018) Computerised interventions designed to reduce potentially inappropriate prescribing in hospitalised older adults: a systematic review and meta-analysis. Age Ageing 47:670–678
Beuscart J-B, Knol W, Cullinan S, Schneider C, Dalleur O, Boland B et al (2018) International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy. BMC Med 16:21
O’Connor MN, O’Sullivan D, Gallagher PF, Eustace J, Byrne S, O’Mahony D (2016) Prevention of hospital-acquired adverse drug reactions in older people using screening tool of older persons’ prescriptions and screening tool to alert to right treatment criteria: a cluster randomized controlled trial. J Am Geriatr Soc 64:1558–1566
O’Mahony D (2016) Explicit criteria for potentially inappropriate prescribing in older people: which set to choose? Eur Geriatr Med 7:394–396
Spinewine A, Swine C, Dhillon S, Lambert P, Nachega JB, Wilmotte L et al (2007) Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial. J Am Geriatr Soc 55:658–665
Wehling M, Burkhardt H, Kuhn-Thiel A, Pazan F, Throm C, Weiss C et al (2016) VALFORTA: a randomised trial to validate the FORTA (Fit fOR The Aged) classification. Age Ageing 45:262–267
Fiss T, Dreier A, Meinke C, van den Berg N, Ritter CA, Hoffmann W (2011) Frequency of inappropriate drugs in primary care: analysis of a sample of immobile patients who received periodic home visits. Age Ageing 40:66–73
Elliott RA, Martinac G, Campbell S, Thorn J, Woodward MC (2012) Pharmacist-led medication review to identify medication-related problems in older people referred to an Aged Care Assessment Team: a randomized comparative study. Drugs Aging 29:593–605
Huiskes VJB, Burger DM, van den Ende CHM, van den Bemt BJF (2017) Effectiveness of medication review: a systematic review and meta-analysis of randomized controlled trials. BMC Fam Pract 18:5
Lavan AH, O’Mahony D, Gallagher P, Fordham R, Flanagan E, Dahly D et al (2019) The effect of SENATOR (Software ENgine for the Assessment and optimisation of drug and non-drug Therapy in Older peRsons) on incident adverse drug reactions (ADRs) in an older hospital cohort—trial protocol. BMC Geriatr 19:40
Crowley EK, Sallevelt BTGM, Huibers CJA, Murphy KD, Spruit M, Shen Z et al (2020) Intervention protocol: OPtimising thERapy to prevent avoidable hospital Admission in the Multi-morbid elderly (OPERAM): a structured medication review with support of a computerised decision support system. BMC Health Serv Res 20:220
Hoffmann T, Jansen J, Glasziou P (2018) The importance and challenges of shared decision making in older people with multimorbidity. PLoS Med 15:e1002530
Tinetti ME, Fried TR, Boyd CM (2012) Designing health care for the most common chronic condition–multimorbidity. JAMA 307:2493–2494
American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. Patient-centered care for older adults with multiple chronic conditions: a stepwise approach from the American Geriatrics Society: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. J Am Geriatr Soc. 2012;60:1957–68.
Barry MJ, Edgman-Levitan S (2012) Shared decision making–pinnacle of patient-centered care. N Engl J Med 366:780–781
Hoffmann TC, Montori VM, Del Mar C (2014) The connection between evidence-based medicine and shared decision making. JAMA 312:1295–1296
Joseph-Williams N, Elwyn G, Edwards A (2014) Knowledge is not power for patients: a systematic review and thematic synthesis of patient-reported barriers and facilitators to shared decision making. Patient Educ Couns 94:291–309
Holmes HM, Todd A (2017) The role of patient preferences in deprescribing. Clin Geriatr Med 33:165–175
Mangin D, Stephen G, Bismah V, Risdon C (2016) Making patient values visible in healthcare: a systematic review of tools to assess patient treatment priorities and preferences in the context of multimorbidity. BMJ Open 6:e010903
van Summeren JJGT, Haaijer-Ruskamp FM, Schuling J (2016) Eliciting preferences of multimorbid elderly adults in family practice using an outcome prioritization tool. J Am Geriatr Soc 64:e143–e148
Tinetti ME, Naik AD, Dindo L, Costello DM, Esterson J, Geda M, et al. Association of Patient Priorities-Aligned Decision-Making With Patient Outcomes and Ambulatory Health Care Burden Among Older Adults With Multiple Chronic Conditions: A Nonrandomized Clinical Trial. JAMA Intern Med. 2019.
Schulman-Green DJ, Naik AD, Bradley EH, McCorkle R, Bogardus ST (2006) Goal setting as a shared decision making strategy among clinicians and their older patients. Patient Educ Couns 63:145–151
Weir K, Nickel B, Naganathan V, Bonner C, McCaffery K, Carter SM et al (2018) Decision-making preferences and deprescribing: perspectives of older adults and companions about their medicines. J Gerontol B Psychol Sci Soc Sci 73:e98-107
Bunn F, Goodman C, Russell B, Wilson P, Manthorpe J, Rait G et al (2018) Supporting shared decision making for older people with multiple health and social care needs: a realist synthesis. BMC Geriatr 18:165
Hirschman KB, Joyce CM, James BD, Xie SX, Karlawish JHT (2005) Do Alzheimer’s disease patients want to participate in a treatment decision, and would their caregivers let them? The Gerontologist 45:381–388
Reeve E, Anthony AC, Kouladjian O’Donnell L, Low L-F, Ogle SJ, Glendenning JE et al (2018) Development and pilot testing of the revised Patients’ attitudes towards deprescribing questionnaire for people with cognitive impairment. Australas J Ageing 37:E150–E154
Kuluski K, Gill A, Naganathan G, Upshur R, Jaakkimainen RL, Wodchis WP (2013) A qualitative descriptive study on the alignment of care goals between older persons with multi-morbidities, their family physicians and informal caregivers. BMC Fam Pract 14:133
Hofman CS, Makai P, Blom JW, Boter H, Buurman BM, Olde Rikkert MGM et al (2015) Comparing the health state preferences of older persons, informal caregivers and healthcare professionals: a vignette study. PLoS ONE 10:e0119197
Carman KL, Dardess P, Maurer M, Sofaer S, Adams K, Bechtel C et al (2013) Patient and family engagement: a framework for understanding the elements and developing interventions and policies. Health Aff Proj Hope 32:223–231
Légaré F, Thompson-Leduc P (2014) Twelve myths about shared decision making. Patient Educ Couns 96:281–286
Marien S, Krug B, Spinewine A (2017) Electronic tools to support medication reconciliation: a systematic review. J Am Med Inform Assoc 24:227–240
Tamblyn R, Winslade N, Lee TC, Motulsky A, Meguerditchian A, Bustillo M et al (2018) Improving patient safety and efficiency of medication reconciliation through the development and adoption of a computer-assisted tool with automated electronic integration of population-based community drug data: the RightRx project. J Am Med Inform Assoc 25:482–495
Marien S, Legrand D, Ramdoyal R, Nsenga J, Ospina G, Ramon V et al (2018) A web application to involve patients in the medication reconciliation process: a user-centered usability and usefulness study. J Am Med Inform Assoc 25:1488–1500
Prey JE, Polubriaginof F, Grossman LV, Masterson Creber R, Tsapepas D, Perotte R et al (2018) Engaging hospital patients in the medication reconciliation process using tablet computers. J Am Med Inform Assoc 25:1460–1469
Plaisant C, Wu J, Hettinger AZ, Powsner S, Shneiderman B (2015) Novel user interface design for medication reconciliation: an evaluation of Twinlist. J Am Med Inform Assoc 22:340–349
Agrawal A, Wu WY (2009) Reducing medication errors and improving systems reliability using an electronic medication reconciliation system. Jt Comm J Qual Patient Saf Jt Comm Resour 35:106–114
Schnipper JL, Hamann C, Ndumele CD, Liang CL, Carty MG, Karson AS et al (2009) Effect of an electronic medication reconciliation application and process redesign on potential adverse drug events: a cluster-randomized trial. Arch Intern Med 169:771–780
Showalter JW, Rafferty CM, Swallow NA, Dasilva KO, Chuang CH (2011) Effect of standardized electronic discharge instructions on post-discharge hospital utilization. J Gen Intern Med 26:718–723
Meulendijk MC, Spruit MR, Drenth-van Maanen AC, Numans ME, Brinkkemper S, Jansen PAF et al (2015) Computerized decision support improves medication review effectiveness: an experiment evaluating the STRIP assistant’s usability. Drugs Aging 32:495–503
Huibers CJA, Sallevelt BTGM, de Groot DA, Boer MJ, van Campen JPCM, Davids CJ et al (2019) Conversion of STOPP/START version 2 into coded algorithms for software implementation: a multidisciplinary consensus procedure. Int J Med Inf 125:110–117
Soiza RL, Subbarayan S, Antonio C, Cruz-Jentoft AJ, Petrovic M, Gudmundsson A et al (2017) The SENATOR project: developing and trialling a novel software engine to optimize medications and nonpharmacological therapy in older people with multimorbidity and polypharmacy. Ther Adv Drug Saf 8:81–85
Sutton RT, Pincock D, Baumgart DC, Sadowski DC, Fedorak RN, Kroeker KI (2020) An overview of clinical decision support systems: benefits, risks, and strategies for success. NPJ Digit Med. https://doi.org/10.1038/s41746-020-0221-y
Rommers MK, Zwaveling J, Guchelaar H-J, Teepe-Twiss IM (2013) Evaluation of rule effectiveness and positive predictive value of clinical rules in a Dutch clinical decision support system in daily hospital pharmacy practice. Artif Intell Med 59:15–21
de Wit HAJM, Mestres Gonzalvo C, Cardenas J, Derijks HJ, Janknegt R, van der Kuy PHM et al (2015) Evaluation of clinical rules in a standalone pharmacy based clinical decision support system for hospitalized and nursing home patients. Int J Med Inf 84:396–405
Boockvar KS, Santos SL, Kushniruk A, Johnson C, Nebeker JR (2011) Medication reconciliation: barriers and facilitators from the perspectives of resident physicians and pharmacists. J Hosp Med 6:329–337
Curatolo N, Gutermann L, Devaquet N, Roy S, Rieutord A (2015) Reducing medication errors at admission: 3 cycles to implement, improve and sustain medication reconciliation. Int J Clin Pharm 37:113–120
Porcelli PJ, Waitman LR, Brown SH (2010) A review of medication reconciliation issues and experiences with clinical staff and information systems. Appl Clin Inform 1:442–461
Lesselroth BJ, Adams K, Tallett S, Wood SD, Keeling A, Cheng K et al (2013) Design of admission medication reconciliation technology: a human factors approach to requirements and prototyping. HERD Health Environ Res Des J 6:30–48
Hoffer GJ (2002) Coordinating mechanisms in care provider groups: relational coordination as a mediator and input uncertainty as a moderator of performance effects. Manag Sci 48:1408–1426
Orlikowski WJ, Scott SV (2008) 10 sociomateriality: challenging the separation of technology, work and organization. Acad Manag Ann 2:433–474
Wawrzyniak C, Marcilly R, Douze L, Pelayo S (2020) Implementing a person-centered medication review process at hospital: recommendations based on a scoping review of barriers and facilitators. Eur J Pers Centered Healthc 7:547–575
van Sluisveld N, Zegers M, Natsch S, Wollersheim H (2012) Medication reconciliation at hospital admission and discharge: insufficient knowledge, unclear task reallocation and lack of collaboration as major barriers to medication safety. BMC Health Serv Res 12:170
White CM, Schoettker PJ, Conway PH, Geiser M, Olivea J, Pruett R et al (2011) Utilising improvement science methods to optimise medication reconciliation. BMJ Qual Saf 20:372–380
Meguerditchian AN, Krotneva S, Reidel K, Huang A, Tamblyn R (2013) Medication reconciliation at admission and discharge: a time and motion study. BMC Health Serv Res 13:485
J C, M C, M O, B D. Medication reconciliation: the priority that isn’t. Healthc Q Tor Ont. 2013;16:32–5.
Wawrzyniak C, Beuscart-Zephir M-C, Marcilly R, Douze L, Beuscart J-B, Lecoutre D et al (2015) Medication review: human factors study aiming at helping an acute geriatric unit to sustain and systematize the process. Stud Health Technol Inform 218:80–85
Xiao Y, Parker SH, Manser T (2013) Teamwork and collaboration. Rev Hum Factors Ergon 8:55–102
Ginnett RC (2019) Crews as groups: their formation and their leadership. In: Kanki BG, Anca J, Chidester TR (eds) Crew resource management, 3rd edn. Academic Press, New York, pp 73–102. https://doi.org/10.1016/B978-0-12-812995-1.00003-8
Acknowledgements
We thank David Fraser PhD (Biotech Communication SARL, Ploudalmézeau, France) for copy-editing assistance.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Beuscart, JB., Pelayo, S., Robert, L. et al. Medication review and reconciliation in older adults. Eur Geriatr Med 12, 499–507 (2021). https://doi.org/10.1007/s41999-021-00449-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s41999-021-00449-9