Skip to main content

Advertisement

SpringerLink
Log in

Antimicrobial photodynamic therapy for periodontal and peri-implant disease

  • Techniques
  • Published:
Clinical Dentistry Reviewed Aims and scope Submit manuscript

Abstract

The main goal in periodontal treatment is to eradicate or at least reduce microbial population. Different wavelengths have been shown to be effective in reducing bacteria in this field. Among different laser procedures, antimicrobial photodynamic therapy (aPDT) has gained special attention due to its minimally invasive manner and safety. It uses light of a specific wavelength to activate a photosensitizer in the presence of oxygen to produce cytotoxic products which leads to cell death. Various types of chemical photosensitizers can be used. Among them are toluidine blue, methylene blue and indocyanine green were used. Recently, natural photosensitizers such as phycocyanin, curcumin and riboflavin have gained are introduced. This new approach of using aPDT with natural and chemical photosensitizers with potential biological activities can be beneficial as an adjunct to conventional therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

Further Reading

  1. Coluzzi DJ, Parker S. (Eds), Lasers in dentistry-current concepts, textbooks in contemporary dentistry. Laser treatment of periodontal and peri-implant disease. https://doi.org/10.1007/978-3-319-51944-9_14

  2. Papapanou P et al (2018) Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol 89(Suppl 1):S173–S182. https://doi.org/10.1002/JPER.17-0721

    Article  Google Scholar 

  3. Parker S (2013) The use of diffuse laser photonic energy and indocyanine green photosensitizer as an adjunct to periodontal therapy. Br Dent J 215(4):167–171

    Article  Google Scholar 

  4. Rajesh S, Koshi E, Philip K, Mohan A (2011) Antimicrobial photodynamic therapy: an overview. J Indian Soc Periodontol 15(4):323–327

    Article  Google Scholar 

  5. Sridharan G, Shankar AA (2012) Toluidine blue: a review of its chemistry and clinical utility. J Oral Maxillofac Pathol 16(2):251–255

    Article  Google Scholar 

  6. Araújo NC, Fontana CR, Bagnato VS, Gerbi ME (2014) Photodynamic antimicrobial therapy of curcumin in biofilms and carious dentine. Lasers Med Sci 29(2):629–635

    Article  Google Scholar 

  7. Cieplik F, Tabenski L, Buchalla W, Maisch T (2014) Antimicrobial photodynamic therapy for inactivation of biofilms formed by oral key pathogens. Front Microbiol 5:405

    Article  Google Scholar 

  8. Prasanth CS, Karunakaran SC, Paul AK, Kussovski V, Mantareva V, Ramaiah D, Selvaraj L, Angelov I, Avramov L, Nandakumar K, Subhash N (2014) Antimicrobial photodynamic efficiency of novel cationic porphyrins towards periodontal Gram-positive and Gram-negative pathogenic bacteria. Photochem Photobiol 90(3):628–640

    Article  Google Scholar 

  9. Chiniforush N, Pourhajibagher M, Parker S, Benedicenti S, Bahador A, Sălăgean T, Bordea IR (2020) The effect of antimicrobial photodynamic therapy using chlorophyllin-phycocyanin mixture on Enterococcus faecalis: the influence of different light sources. Appl Sci 10(12):4290. https://doi.org/10.3390/app10124290

    Article  Google Scholar 

  10. Etemadi A, Hamidain M, Parker S, Chiniforush N (2021) Blue Light photodynamic therapy with curcumin and riboflavin in the management of periodontitis: a systematic Review. J Lasers Med Sci 21(12):e15. https://doi.org/10.34172/jlms.2021.15.PMID:34733738;PMCID:PMC8558718

    Article  Google Scholar 

  11. Chiniforush N, Pourhajibagher M, Shahabi S, Kosarieh E, Bahador A (2016) Can antimicrobial photodynamic therapy (aPDT) enhance the endodontic treatment? J Lasers Med Sci 7(2):76–85. https://doi.org/10.15171/jlms.2016.14 (PMID: 27330702; PMCID: PMC4909016)

    Article  Google Scholar 

  12. Hashemikamangar SS, Alsaedi RJF, Chiniforush N, Motevaselian F (2022) Effect of antimicrobial photodynamic therapy with different photosensitizers and adhesion protocol on the bond strength of resin composite to sound dentin. Clin Oral Investig. https://doi.org/10.1007/s00784-022-04370-8 (PMID: 35029748)

    Article  Google Scholar 

  13. Shahmohammadi R, Younespour S, Paknejad M, Chiniforush N, Heidari M (2022) Efficacy of adjunctive antimicrobial photodynamic therapy to mechanical debridement in the treatment of peri-implantitis or peri-implant mucositis in smokers: a systematic review and meta-analysis. Photochem Photobiol 98(1):232–241. https://doi.org/10.1111/php.13481

    Article  Google Scholar 

  14. Monzavi A, Chinipardaz Z, Mousavi M, Fekrazad R, Moslemi N, Azaripour A, Bagherpasand O, Chiniforush N (2016) Antimicrobial photodynamic therapy using diode laser activated indocyanine green as an adjunct in the treatment of chronic periodontitis: a randomized clinical trial. Photodiagn Photodyn Ther 14:93–97. https://doi.org/10.1016/j.pdpdt.2016.02.007

    Article  Google Scholar 

  15. Moslemi N, Soleiman-Zadeh Azar P, Bahador A, Rouzmeh N, Chiniforush N, Paknejad M, Fekrazad R (2015) Inactivation of Aggregatibacter actinomycetemcomitans by two different modalities of photodynamic therapy using toluidine blue O or radachlorin as photosensitizers: an in vitro study. Lasers Med Sci 30(1):89–94. https://doi.org/10.1007/s10103-014-1621-5

    Article  Google Scholar 

  16. Chambrone L, Wang HL, Romanos GE (2018) Antimicrobial photodynamic therapy for the treatment of periodontitis and peri-implantitis: an American academy of periodontology best evidence review. J Periodontol 89(7):783–803. https://doi.org/10.1902/jop.2017.170172

    Article  Google Scholar 

  17. Sanz M, Herrera D, Kebschull M et al (2020) Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline [published correction appears in. J Clin Periodontol 47(Suppl 22):4–60. https://doi.org/10.1111/jcpe.13290 (2021 Jan;48(1):163)

    Article  Google Scholar 

  18. Peron D et al (2019) Photodynamic antimicrobial chemotherapy has an overt killing effect on periodontal pathogens? A systematic review of experimental studies. Lasers Med Sci 34:1527–1534. https://doi.org/10.1007/s10103-019-02806-4

    Article  Google Scholar 

  19. Husenjnagic S et al (2019) Photoactivated disinfection in periodontal treatment: A randomized controlled clinical split-mouth trial. J Periodontol 90:1260–1269. https://doi.org/10.1002/JPER.18-0576

    Article  Google Scholar 

  20. Salvi GE et al (2020) Adjunctive laser or antimicrobial photodynamic therapy to nonsurgical mechanical instrumentation in patients with untreated periodontitis: a systematic review and meta-analysis. J Clin Periodontol 47:176–198. https://doi.org/10.1111/jcpe.13236

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Qouds Ave, Tehran, Iran

    Nasim Chiniforush

  2. Preventive and Restorative Dental Sciences, School of Dentistry, University of California, San Francisco, CA, USA

    Don Coluzzi

  3. Photoperiodontics, Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Akira Aoki

Authors
  1. Nasim Chiniforush
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Don Coluzzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Akira Aoki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nasim Chiniforush.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chiniforush, N., Coluzzi, D. & Aoki, A. Antimicrobial photodynamic therapy for periodontal and peri-implant disease. Clin Dent Rev 6, 9 (2022). https://doi.org/10.1007/s41894-022-00123-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s41894-022-00123-8

Keywords

Search

Navigation