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Sleep Apnea Severity in People with Acromegaly: Analysis of Data from Iranian Pituitary Tumor Registry (IPTR)

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Abstract

Background

Sleep apnea is a most common respiratory disorder in patients with acromegaly responsible for cardiovascular complications. This study aimed to evaluate the risk factors associated with severity of sleep apnea in people with acromegaly.

Methods

We included 56 patients with acromegaly referred to a tertiary pituitary clinic between 2019 and 2020. All patients were assessed by Epworth sleepiness scale (ESS) questionnaire and overnight polysomnography.

Results

Patients with severe sleep apnea who need continuous positive airway pressure (CPAP) treatment were older (OR; 1.08, 95% CI 1.02–1.14, p = 0.010) and had higher waist circumference (OR; 1.08; 1.02–1.15, p = 0.015).

Conclusion

In patients with acromegaly, age and waist circumference seem to be the main determinants of severe sleep apnea.

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Data Availability

Any materials and data that are reasonably requested by others are available from the authors.

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Acknowledgements

The authors wish to thank all people who participated in this study.

Funding

No Fund.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Firoozgar Hospital, Iran University of Medical Science, Tehran, Iran

    Zeinab Abazari & Mahdi Yadollahzadeh

  2. Department of Radiology, Firouzgar Clinical Research Development Center(FCRDC), Iran University of Medical Sciences(IUMS), Tehran, Iran

    Manizhe Ataee Kachuee

  3. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, No. 10, Firoozeh St., Vali-Asr Ave., Vali-Asr Sq., Tehran, Iran

    Nahid Hashemi-Madani, Zahra Emami & Mohammad E. Khamseh

  4. Division of Vascular and Endovascular Neurosurgery, Firoozgar Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran

    Mohammad Ghorbani

Authors
  1. Zeinab Abazari
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  2. Mahdi Yadollahzadeh
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  3. Manizhe Ataee Kachuee
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  4. Nahid Hashemi-Madani
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  5. Zahra Emami
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  6. Mohammad Ghorbani
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  7. Mohammad E. Khamseh
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Contributions

NH-M and ZA contributed to the conception and design of the study; ZA, ZE, MY, MAK, and MG contributed to the literature search, data extraction, and quality assessment; MEK, NH-M, and ZA contributed to data analysis and writing of the manuscript. All authors approved the manuscript.

Corresponding author

Correspondence to Nahid Hashemi-Madani.

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Conflict of Interest

All authors declare no competing interests.

Ethical Approval

The study was approved by the ethics committee of the Iran University of Medial Sciences. (IR.IUMS.FMD.REC1399.353).

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Written informed consent was obtained from participants.

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Abazari, Z., Yadollahzadeh, M., Kachuee, M.A. et al. Sleep Apnea Severity in People with Acromegaly: Analysis of Data from Iranian Pituitary Tumor Registry (IPTR). Sleep Vigilance 7, 187–193 (2023). https://doi.org/10.1007/s41782-023-00244-5

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  • DOI: https://doi.org/10.1007/s41782-023-00244-5

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