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Investigation of collagen/tricalcium silicate/carboxymethyl cellulose composite bone glue for drug controlled release

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Abstract

A novel bone glue composed of tricalcium silicate and high proportion of type I collagen is proposed. Tricalcium silicate (C3S) is one of the most promising biomedical materials on bone cement due to its excellent biocompatibility and self-curing properties. By adding the type I collagen and carboxymethyl cellulose (CMC) to increase the adhesion and biocompatibility to the human tissue, the proposed composite bone glue shows excellent adhesive strength to 416 kPa, tensile strength to 167 kPa, and increasing mechanical strength after curing in simulated body fluid. Furthermore, results of diclofenac sodium drug releasing test show that after 2 days, the release increased from 46 to 53% and then maintained about 53%. Among all different collagen to C3S ratio, 40 wt% collagen and 60 wt% C3S composite bone glue has great potential to be a novel bone glue carrying with drugs.

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Acknowledgements

The authors are grateful for the part sponsor of this research by the Ministry of Science and Technology of the Republic of China, under Grant Nos. MOST 104-2622-E-027-027-CC3, MOST 104-2221-E-027-061, and MOST 105-2221-E-027-028, and part from the National Taipei University of Technology-Mackay Memorial Hospital Joint Research, under Grant No. MMH-TT-10401. The first, second, and third authors contributed equally to this work.

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Authors and Affiliations

  1. Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei, 106, Taiwan, Republic of China

    Ren-Jei Chung, An-Ni Wang & Yi-Chung Wu

  2. Dentistry, Mackay Memorial Hospital, Taipei, 104, Taiwan, Republic of China

    Huey-Yuan Wang

  3. Mackay Medicine, Nursing and Management College, Taipei, 112, Taiwan, Republic of China

    Huey-Yuan Wang

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  1. Ren-Jei Chung
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  2. An-Ni Wang
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  3. Huey-Yuan Wang
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  4. Yi-Chung Wu
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Corresponding author

Correspondence to Ren-Jei Chung.

Appendix

Appendix

Fig. 15
figure 15

Bone glue adhesion test using SD rat skull model, where two small pieces of skull bones were glued using the proposed material, and then, the whole setting was soaked in PBS solution at 37 °C; detailed experimental procedure is as described in the article

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Chung, RJ., Wang, AN., Wang, HY. et al. Investigation of collagen/tricalcium silicate/carboxymethyl cellulose composite bone glue for drug controlled release. J Aust Ceram Soc 53, 329–342 (2017). https://doi.org/10.1007/s41779-017-0042-x

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  • DOI: https://doi.org/10.1007/s41779-017-0042-x

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