Abstract
In recent years, preimplantation genetic testing (PGT) of IVF embryos have gained much traction in clinical assisted reproduction for preventing various genetic defects, including Down syndrome. However, such genetic tests inevitably reveal the sex of IVF embryos by identifying the sex (X and Y) chromosomes. In many countries with less stringent IVF regulations, information on the sex of embryos that are tested to be genetically normal is readily shared with patients. This would thus present Muslim patients with unintended opportunities for sex selection based on personal or social biases without any pressing need or valid medical reason. Additionally, there are other patients who claim using PGT for preventing genetic defects as a pretext or “convenient excuse,” with a secret intention to do sex selection when it is banned in their home country. Currently, non-medical sex selection is a highly-controversial and hotly debated issue in Islam, because there is generally a strong preference for having sons over daughters due to widespread cultural norms of elderly parents depending on their sons for financial support, as well as the need for male heirs to continue the family lineage within the backdrop of local patriarchal cultures. There is a risk of gender imbalance and social disequilibrium occurring in Islamic societies due to prevalent sex selection. Hence, the question is whether opportunistic sex selection with PGT would contravene Islamic ethics and principles, which will thus be discussed here.
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References
Al-Bazz, A.A.M. 2001. Ikhtiyār Jins al-Mawlūd wa Taḥdīdihi Qabla Takhaluqqihi wa wilādatihi bayna al-Ṭibb wa al-Fiqh, in al-Ahqar ʿUmar Sulyaman et al (Ed.), Dirāsah Fiqhiyyah fī Qaḍāyā al-Ṭibbiyyah al-Muʿāṣirah. Jordan: Dār al-Nafā’is..
Al-Shuwayrikh, S. 2007. Aḥkām Al-Handasah Al-Wirāthiyyah. KSA: Dār Kunūz Ishbīliya.
American College of Medical Genetics and Genomics. 2014. ACMG updates recommendation on “opt out” for genome sequencing return of results. https://www.acmg.net/docs/Release_ACMGUpdatesRecommendations_final.pdf. Accessed 4 Sept 2023.
Arif, A.A. 2011. Qaḍāyā Fiqhiyyah fī Naql al-Aʿḍā’ al-Bashariyyah, 175–176. Kuala Lumpur: IIUM.
Bokek-Cohen, Y., and M. Tarabeih. 2020. Forbidden medically assisted sex selection in Sunni Muslims: A qualitative study. Reproductive Biomedicine Online 41 (3): 534–542. https://doi.org/10.1016/j.rbmo.2020.05.018.
Burke, W., A.H. Antommaria, R. Bennett, J. Botkin, E.W. Clayton, and G.E. Henderson. 2013. Recommendations for returning genomic incidental findings? We need to talk! Genetics in Medicine 15: 10. https://doi.org/10.1038/gim.2013.113.
Dezhkam, L., H. Dezhkam, and I. Dezhkam. 2014. Sex selection from Islamic point of view. Iranian Journal of Reproductive Medicine 12 (4): 289–290.
Dondorp, W., G. De Wert, G. Pennings, F. Shenfield, P. Devroey, B. Tarlatzis, P. Barri, and K. Diedrich. 2013. ESHRE Task Force on ethics and Law 20: Sex selection for non-medical reasons. Human Reproduction 28 (6): 1448–1454. https://doi.org/10.1093/humrep/det109.
Eftekhaari, T.E., A.A. Nejatizadeh, M. Rajaei, S. Soleimanian, S. Fallahi, R. Ghaffarzadegan, and F. Mahmoudi. 2015. Ethical considerations in sex selection. Journal of Education Health Promotion 19 (4): 32. https://doi.org/10.4103/2277-9531.157184.
Ethics Committee of the American Society for Reproductive Medicine. 2018. Disclosure of sex when incidentally revealed as part of preimplantation genetic testing (PGT): An ethics committee opinion. Fertility and Sterility 110 (4): 625–627. https://doi.org/10.1016/j.fertnstert.2018.06.019.
Ethics Committee of the American Society for Reproductive Medicine. 2022. Use of reproductive technology for sex selection for nonmedical reasons: An ethics committee opinion. Fertility and Sterility 117 (4): 720–726. https://doi.org/10.1016/j.fertnstert.2021.12.024.
Fesahat, F., F. Montazeri, and S.M. Hoseini. 2020. Preimplantation genetic testing in assisted reproduction technology. Journal of Gynecology Obstetrics and Human Reproduction 49 (5): 101723. https://doi.org/10.1016/j.jogoh.2020.101723.
Islamweb.net. Fatwa number 6469. 2022. islamweb.net/ar/fatwa/6469/مكح-يننللا-سلج-نيدلتل-ينملا-لصف
Kalia, S.S., K. Adelman, S.J. Bale, W.K. Chung, C. Eng, and J.P. Evans. 2017. Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): A policy statement of the American College of Medical Genetics and Genomics. Genetics in Medicine 19: 249–255. https://doi.org/10.1038/gim.2016.190.
Knoppers, Bartha M. 2014. From the right to know to the right not to know. Journal of Law, Medicine & Ethics 42 (1): 6–10. https://doi.org/10.1111/jlme.12113.
Malpani, A., A. Malpani, and D. Modi. 2002. Preimplantation sex selection for family balancing in India. Human Reproduction 17 (1): 11–12. https://doi.org/10.1093/humrep/17.1.11.
Misachi, John. 2021. Countries where men far outnumber women. World Atlas. https://www.worldatlas.com/articles/countries-where-men-outnumber-women.html. Accessed 15 Aug 2023.
Qāsim, A.R. 2001. Ikhtiyār jins al-Janīn Dirāsah Fiqhiyyah Ṭibbiyah. Taif: Maktabat Dar al-Bayān Al-Ḥadīthah.
Rai, P., A. Ganguli, S. Balachandran, R. Gupta, and S.B. Neogi. 2018. Global sex selection techniques for family planning: A narrative review. Journal of Reproductive and Infant Psychology 36 (5): 548–560. https://doi.org/10.1080/02646838.2018.1508871.
Saed Al-Nadi M. 2018. Ikhtiyar Jins Al-Janin Fi Daw' Al-Fiqh Al-Islami: Dirasah Muqaranah. Majallat Kulliyah al-Sharīʿah wa al-Qānūn bi Tafahnah Al Ashraf. 20(1): 79–136. https://doi.org/10.21608/jfslt.2018.10759
Shaia, K., T. Truong, C. Pieper, and A. Steiner. 2020. Pre-implantation genetic testing alters the sex ratio: An analysis of 91,805 embryo transfer cycles. Journal of Assisted Reproduction and Genetics 37 (5): 1117–1122. https://doi.org/10.1007/s10815-020-01746-1
Wolf, S.M., G.J. Annas, and S. Elias. 2013. Patient autonomy and incidental findings in clinical genomics. Science 340: 1049–1050. https://doi.org/10.1126/science.1239119.
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Muhsin, S.M., Arab, S.Z. & Chin, A.H.B. Islamic Viewpoints on Opportunistic Sex Selection of IVF Embryos upon doing Preimplantation Genetic Testing for Preventing Genetic Diseases. ABR 16, 223–232 (2024). https://doi.org/10.1007/s41649-023-00258-1
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DOI: https://doi.org/10.1007/s41649-023-00258-1