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Metal Complexes of Heterocyclic Hydrazone Schiff-Bases: Preparation, Spectral Characterisation and Biological Study

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Iranian Journal of Science and Technology, Transactions A: Science Aims and scope Submit manuscript

Abstract

New isatinic hydrazone Schiff-base ligands, namely furan-2-carboxylic acid (2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazide (L1), thiophene-2-carboxylic acid (2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazide (L2) and 2-(pyridine-2-yl-hydrazono)-1,2-dihydro-indol-3-one) (L3) are reported. The ligands were prepared by the condensation of furan-2-carboxylic acid hydrazide (L1), thiophene-2-carboxylic acid hydrazide (L2), and 2-hydrazino pyridine (L3) with isatine. Monomeric complexes were prepared from the reaction of the corresponding metal chloride with the ligands. The ligands and their nine new complexes of the general formulae [M(Ln)2]Cl2 [where M = Co(II), Zn(II) and Cd(II); n = L1, L2 and L3] were characterised by spectroscopic methods (FTIR, UV–Vis, 1H, 13C NMR), elemental analysis, metal content, magnetic measurement and molar conductance. These studies revealed the formation of six coordinate complexes, in which the geometry about metal atom is a distorted octahedral. Biological activity of the ligands and their metal complexes against Gram-positive bacterial strain Bacillus (G+) and Gram-negative bacteria Ecoli (G−) are evaluated. The effects of prepared compounds depend on the type of tested bacteria. It is clear that the ligands and their metal complexes have a potential effect on the Gram-positive (G+) and Gram-negative (G−) strains of the tested bacteria.

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Authors and Affiliations

  1. Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Adhamiyah, P.O. Box 4150, Baghdad, Iraq

    Enaam I. Yousif, Riyadh M. Ahmed, Hasan A. Hasan & Mohamad J. Al-Jeboori

  2. Department of Chemistry, College of Science, University of Al-Anbar, Al-Ramadi, Iraq

    Aeed S. Al-Fahdawi

Authors
  1. Enaam I. Yousif
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  2. Riyadh M. Ahmed
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  3. Hasan A. Hasan
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  4. Aeed S. Al-Fahdawi
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  5. Mohamad J. Al-Jeboori
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Correspondence to Mohamad J. Al-Jeboori.

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Yousif, E.I., Ahmed, R.M., Hasan, H.A. et al. Metal Complexes of Heterocyclic Hydrazone Schiff-Bases: Preparation, Spectral Characterisation and Biological Study. Iran J Sci Technol Trans Sci 41, 103–109 (2017). https://doi.org/10.1007/s40995-017-0187-z

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  • DOI: https://doi.org/10.1007/s40995-017-0187-z

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